Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

SmartSeq2 analysis of chemically-defined MiPs with and without valproic acid treatment

ABSTRACT: SmartSeq2 analysis of chemically-defined MiPs with and without valproic acid treatment

PROVIDER: PRJNA736970 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR14788400.fastq.gz	Fastqsanger.gz
	SRR14788500.fastq.gz	Fastqsanger.gz
	SRR14788600.fastq.gz	Fastqsanger.gz
	SRR14788401.fastq.gz	Fastqsanger.gz
	SRR14788501.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 288

Similar Datasets

SmartSeq2 analysis of chemically-defined MiPs with and without valproic acid treatment

Project description:We have optimized a protocol to generate chemically defined induced pluripotent stem cell-derived mesodermal progenitors. We demonstrate that these cells contribute to myotube formation that can be improved by the addition of valproic acid. Thanks to SmartSeq2 single cell RNAseq, we show that valproic acid treatment increase the number of myogenic progenitors. We also used gene set enrichment analysis to annotate the clusters further with correlations to the ARCHS4 Tissues database. In particular, we found that the gene expression profile of the VPA-treated single cell cluster correlated more to myoblasts compared to the untreated cells. Some key myogenic genes found to be differentially expressed were DESMIN and CD82, which were upregulated upon VPA supplementation.

2021-06-12 | GSE177048 | GEO

Transcription profiling of human embryonic stem cells and their differentiated progeny grown in chemically defined conditions

Project description:Comparison of H9 human embryonic stem cells, grown in chemically defined and animal-product free conditions, with their differentiated progeny - mesendodermal progenitors arisen as the result of changes made to chemically defined hESC growth conditions. Contributes to a larger work on the use of chemically defined growth conditions to direct hESC differentiation.

2009-07-31 | E-MEXP-930 | biostudies-arrayexpress

Transcription profling of human embryonic stem cells differentiated into endoderm progenitors in chemically-defined media.

Project description:Human embryonic stem cells differentiated into endoderm progenitors in chemically-defined media.

2010-04-02 | E-MEXP-2373 | biostudies-arrayexpress

Transcription profiling of human embryonic stem cells in response to valproic acid and valproic acid analogs

Project description:Transcriptional profiling of valproic acid and valproic acid analogs in human embryonic stem cells.

2010-12-31 | E-MEXP-2374 | biostudies-arrayexpress

Nervous system development related gene expression regulation in the zebrafish embryo after exposure to valproic acid and retinoic acid: a genome wide approach

Project description:In our search for biomarkers of maldevelopment, we focused on chemically-induced perturbation of the retinoic acid signaling pathway (RA-SP), a major pathway implicated in a plethora of developmental processes. A genome-wide expression screening was was performed on zebrafish embryos treated with two teratogens, all-trans retinoic acid (ATRA) and valproic acid (VPA), and a negative control, folic acid (FA).

2024-03-15 | GSE226367 | GEO

Identification differentially expressed genes upon valproic acid treatment

Project description:The goal of this study is to define genes that are differentially expressed in Down syndrome leukemic blasts after treatment with valproic acid (VPA) Here we report the identification gene sets that are downregulated in Down syndrome leukemic cell lines after exposure to valproic acid (VPA)

2011-07-13 | GSE30517 | GEO

Preoperative Valproic Acid and Radiation Therapy for Rectal Cancer

Project description:The purpose of this study is to first determine the maximum tolerated dose of capecitabine given alone or in combination with valproic acid during preoperative short-course radiotherapy (Phase 1). The next part of the study (Phase 2)will explore whether the addition of valproic acid or the addition of capecitabine to short-course radiotherapy, before optimal radical surgery might increase the pathologic complete tumor regression rate in patients with low-moderate risk rectal cancer.

| 2148214 | ecrin-mdr-crc

Porcine oocytes matured in a chemically defined medium are transcriptionally active

Project description:Porcine oocytes matured in a chemically defined medium are transcriptionally active

| PRJNA898618 | ENA

Antileukemic activity of valproic acid in chronic lymphocytic leukemia cells defined by microarray analysis

Project description:Epigenetic code modifications by histone deacetylase inhibitors (HDACi) have recently been proposed as potential new therapies for hematological malignancies. Chronic Lymphocytic Leukemia (CLL) remains incurable despite the introduction of new treatments. CLL cells are characterized by an apoptosis defect rather than excessive proliferation, but proliferation centers have been found in organs such as bone marrow and lymph nodes. Here, we investigated gene expression modifications in CLL cells following treatment with valproic acid (VPA), a well-tolerated anti-epileptic drug with HDAC inhibitory activity.

2009-08-24 | GSE14973 | GEO

Transcriptional response of Streptococcus mutans in chemically defined medium (CDM) towards the autoinducers CSP and XIP

Project description:S. mutans UA159 was cultivated in chemically defined medium. Changes in the transcriptome in response to the autoinducing peptides CSP and XIP were monitored for 30 minutes.

2015-06-01 | GSE65982 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data