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DDX18 coordinates nucleolus phase separation and chromatin organization to control the pluripotency of human embryonic stem cells [RNA-seq]

ABSTRACT: DDX18 coordinates nucleolus phase separation and chromatin organization to control the pluripotency of human embryonic stem cells [RNA-seq]

PROVIDER: PRJNA757953 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15647541.fastq.gz	Fastqsanger.gz
	SRR15647542.fastq.gz	Fastqsanger.gz
	SRR15647543.fastq.gz	Fastqsanger.gz
	SRR15647544.fastq.gz	Fastqsanger.gz
	SRR15647545.fastq.gz	Fastqsanger.gz

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DDX18 coordinates nucleolus phase separation and nuclear organization to control the pluripotency of human embryonic stem cells

Project description:Pluripotent stem cells are unique in their large nucleus and manifestly open chromatin structure with hypertranscriptional activities. How the nucleolus, the largest membraneless and phase-separated subnuclear organelle, maintains its structural integrity in pluripotency maintenance remains incompletely understood. By studying nucleolus-specific DEAD-box RNA helicase-18 (DDX18) in human embryonic stem cells, we discover mechanisms controlling nucleolus phase separation and chromatin organization.

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SILAC of hESCs with DDX18 knockdown

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DDX18 coordinates nucleolus phase separation and chromatin organization to control the pluripotency of human embryonic stem cells [DDX18_iCLIP-seq]

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DDX18 coordinates nucleolus phase separation and chromatin organization to control the pluripotency of human embryonic stem cells [DDX18_CHIP-seq]

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