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DDX18 coordinates nucleolus phase separation and nuclear organization to control the pluripotency of human embryonic stem cells

ABSTRACT: DDX18 coordinates nucleolus phase separation and nuclear organization to control the pluripotency of human embryonic stem cells

PROVIDER: PRJNA758065 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15624022_1.fastq.gz	Fastqsanger.gz
	SRR15624022_2.fastq.gz	Fastqsanger.gz
	SRR15624023_1.fastq.gz	Fastqsanger.gz
	SRR15624023_2.fastq.gz	Fastqsanger.gz
	SRR15624024_1.fastq.gz	Fastqsanger.gz

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DDX18 coordinates nucleolus phase separation and nuclear organization to control the pluripotency of human embryonic stem cells

Project description:Pluripotent stem cells are unique in their large nucleus and manifestly open chromatin structure with hypertranscriptional activities. How the nucleolus, the largest membraneless and phase-separated subnuclear organelle, maintains its structural integrity in pluripotency maintenance remains incompletely understood. By studying nucleolus-specific DEAD-box RNA helicase-18 (DDX18) in human embryonic stem cells, we discover mechanisms controlling nucleolus phase separation and chromatin organization.

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Project description:DDX18 coordinates nucleolus phase separation and chromatin organization to control the pluripotency of human embryonic stem cells.

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SILAC of hESCs with DDX18 knockdown

Project description:This study explores the crucial role of the nucleolus-specific RNA helicase DDX18 in maintaining the pluripotency of human embryonic stem cells. We demonstrate that DDX18 coordinates nucleolus phase separation and chromatin organization by interacting with NPM1 in the granular component of the nucleolus, facilitated by nucleolar RNA species. The absence of DDX18 disrupts immiscible nucleolar substructures, significantly affecting centromere clustering and perinucleolar heterochromatin (PNH) formation.

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DDX18 coordinates nucleolus phase separation and chromatin organization to control the pluripotency of human embryonic stem cells [DDX18_CHIP-seq]

Project description:DDX18 coordinates nucleolus phase separation and chromatin organization to control the pluripotency of human embryonic stem cells [DDX18_CHIP-seq]

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DDX18 coordinates nucleolus phase separation and chromatin organization to control the pluripotency of human embryonic stem cells [DDX18_iCLIP-seq]

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Project description:DDX18 coordinates nucleolus phase separation and chromatin organization to control the pluripotency of human embryonic stem cells [RNA-seq]

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DDX18 coordinates nucleolus phase separation and chromatin organization to control the pluripotency of human embryonic stem cells.

Project description:This SuperSeries is composed of the SubSeries listed below.

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