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Rickettsia parkeri

ABSTRACT: Rickettsia parkeri overview

PROVIDER: PRJNA76087 | ENA |

REPOSITORIES: ENA

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Dataset's files

Source:

			Action	DRS
		Other
	SRR1118730_subreads.fastq.gz	Fastqsanger.gz
	SRR1118731_subreads.fastq.gz	Fastqsanger.gz
	SRR1118732_1.fastq.gz	Fastqsanger.gz
	SRR1118732_2.fastq.gz	Fastqsanger.gz

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Project description:Rickettsia spp. are obligate intracellular bacterial pathogens that have evolved a variety of strategies to exploit their host cell niche. However, the bacterial factors that contribute to this intracellular lifestyle are poorly understood. Here, we show that the conserved ankyrin repeat protein RARP-1 supports Rickettsia parkeri infection. Specifically, RARP-1 promotes efficient host cell entry and growth within the host cytoplasm, but is not necessary for cell-to-cell spread or evasion of host autophagy. We further demonstrate that RARP-1 is not secreted into the host cytoplasm by R. parkeri. Instead, RARP-1 resides in the periplasm, and we identify several binding partners that are predicted to work in concert with RARP-1 during infection. Altogether, our data reveal that RARP-1 plays a critical role in the rickettsial life cycle.

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