Project description:That commensal bacteria can influence intestinal inflammation has been observed using other models of chronic colitis. Loss of IL-10, a major immunosuppressive cytokine, induces spontaneous colitis in mice. The incidence of spontaneous polyp formation in IL-10-deficient mice was also completely eliminated in the absence of STING We used microarrays to evaluate the inflammatory cytokine expression in the colon from IL10 KO mice and IL10/STING KO mice.
Project description:Comparison of kidneys of 4 different Pept2 KO individuals (GSE1585), pool of them and kidneys of WT individuals versus another WT individual (GSE1586). Keywords = Pept2 Keywords = Slc15a2 Keywords = kidney Keywords = KO Keywords = WT Keywords = pool Keywords = pooling Keywords = normal variatons Keywords = C57BL/6 Keywords = 129Sv Keywords: other
Project description:Computational identification of gene expression pathways or key regulatory factors in the Pkd1 KO kidneys treated by salsalate, tolvaptan, and in combination
Project description:Transcriptional profiling of whole kidneys from Six2CreEGFP mice without (WT) or with (KO) homozygously floxed DOT1 alleles at the age of embryonic day 16.5. This experiment aimed to uncover the genome-wide alternation in gene expression resulting from the removal of DOT1 gene in the nephron progenitor population (Six2 positive) and successive changes to the series of events in kidney development.