Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Protective effect of Bifidobacterium against age-related brain damage

PROVIDER: PRJNA770822 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR16307059_1.fastq.gz	Fastqsanger.gz
	SRR16307059_2.fastq.gz	Fastqsanger.gz
	SRR16307060_1.fastq.gz	Fastqsanger.gz
	SRR16307060_2.fastq.gz	Fastqsanger.gz
	SRR16307061_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 32

Similar Datasets

E-GEOD-23914

Project description:Transcription profiling by array of mice which have undergone appendicitis followed by appendectomy (AA) at a young age against those with sham surgery to study the potential protective effect of AA against inflammatory bowel disease

2015-01-06 | E-GEOD-23914 | ExpressionAtlas

E-GEOD-8150

Project description:Transcription profiling of mouse brain to identify age-related transcriptional changes and the effect of dietary supplementation of vitamin E

2015-10-22 | E-GEOD-8150 | ExpressionAtlas

E-GEOD-25007

Project description:Drosophila brain gene expression profile with age

2015-09-16 | E-GEOD-25007 | ExpressionAtlas

In vitro caloric restriction induces protective genes and functional rejuvenation in senescent SAMP8 astrocytes

Project description:Astrocytes are key cells in brain aging, helping neurons to undertake healthy aging or otherwise letting them enter into a spiral of neurodegeneration. We aimed to characterize astrocytes cultured from senescence-accelerated prone 8 (SAMP8) mice, a mouse model of brain pathological aging, along with the effects of caloric restriction, the most effective rejuvenating treatment known so far. Analysis of the transcriptomic profiles of SAMP8 astrocytes cultured in control conditions and treated with caloric restriction serum was performed using mRNA microarrays. A decrease in mitochondrial and ribosome mRNA, which was restored by caloric restriction, confirmed the age-related profile of SAMP8 astrocytes and the benefits of caloric restriction. An amelioration of antioxidant and neurodegeneration-related path- ways confirmed the brain benefits of caloric restriction. Studies of oxidative stress and mitochondrial function demonstrated a reduction of oxidative damage and partial improvement of mito- chondria after caloric restriction. In summary, caloric restriction showed a significant tendency to normalize pathologically aged astrocytes through the activation of pathways that are protective against the age-related deterioration of brain physiology. Key words: astrocytes; caloric restriction; mitochondria; oxidative stress; RNA microarrays; SAMP8.

2015-06-23 | GSE60388 | GEO

Project description:2FL age specific bifidobacterium effect

| PRJNA1177813 | ENA

Project description:Protective effect of baicalin against ulcerative colitis

| PRJNA524458 | ENA

T cell mediated microglia activation triggers myelin pathology in a model of amyloidosis

Project description:Age-related myelin damage induces inflammatory responses, yet its involvement in Alzheimer’s disease (AD) remains uncertain, despite age being a major risk factor. Using a mouse model of AD, we found that amyloidosis itself triggers age-related oligodendrocyte and myelin damage. Mechanistically, CD8+ T cells promote the progressive accumulation of abnormally interferon-activated microglia that display myelin-damaging activity. Thus, immune responses against myelinating oligodendrocytes may contribute to neurodegenerative diseases with amyloidosis.

2024-05-10 | GSE243018 | GEO

T cell mediated microglia activation triggers myelin pathology in a model of amyloidosis [MERFISH]

Project description:Age-related myelin damage induces inflammatory responses, yet its involvement in Alzheimer's disease remains uncertain, despite age being a major risk factor. Using a mouse model of Alzheimer's disease, we found that amyloidosis itself triggers age-related oligodendrocyte and myelin damage. Mechanistically, CD8+ T cells promote the progressive accumulation of abnormally interferon-activated microglia that display myelin-damaging activity. Thus, our data suggest that immune responses against myelinating oligodendrocytes may contribute to neurodegenerative diseases with amyloidosis.

2024-05-14 | GSE243120 | GEO

Loss of p21 expression enhances DNA damage, cholestasis and hepatocarcinogenesis in the liver

Project description:Overexpression of p21 in NEMOM-NM-^Thepa animals protects against DNA damage, acceleration of hepatocarcinogenesis and cholestasis. As strengthened by our LPS stimulation experiments, we identified a novel protective role of p21 against DNA damage. Expression profiling of livers from wild type, NEMO, and NEMO-P21 null mice.

2015-03-01 | E-GEOD-61100 | biostudies-arrayexpress

Microglia protect against age-associated brain pathologies

Project description:Microglia protect against age-associated brain pathologies

| PRJNA1111815 | ENA