Project description:Hypoxia leads to significant changes at the histone modification marks, including increasing methylation of H3K4, H3K9 and H3K27. However, the overall effect on chromatin accessibility is not fully understood. Here, we employed an ATACseq method on PFA-fixed mouse glioma cell line GL261to test the genomewide chromatin accessibility changes in response to two hypoxic conditions: moderate hypoxia (1% O2) and severe hypoxia (<0.1% O2).

2023-03-05 | GSE200757 | GEO

Regulation of Chromatin Accessibility by hypoxia and HIF_1

Project description:ATAC-seq was performed to investigate changes in chromatin accessibility in repsonse to hypoxia

2022-03-04 | GSE186342 | GEO

Regulation of Chromatin Accessibility by hypoxia and HIF_3

Project description:Integrative analysis of RNA-seq with ATAC-seq to investigate changes in chromatin accessibility in repsonse to hypoxia.

2022-03-04 | GSE186370 | GEO

SAFA in chromatin accessibility regulation

Project description:SAFA in chromatin accessibility regulation

| PRJNA821600 | ENA

Hypoxia-induced transcriptome and chromatin accessibility alterations in mouse cardiac cell line HL-1

Project description:In this study, we performed temporal profiling of transcriptome and chromatin accessibility in HL-1 cells for understanding the molecular mechanisms underlying cardiac responses to hypoxia. We collected HL-1 cells under four conditions (4 h and 8 h of hypoxia exposure, 24 h reoxygenation and the normal condition), applied RNA-seq and ATAC-seq to them and performed pairwise comparison of gene expression and open chromatin status on a genome-wide scale.

2021-12-31 | E-MTAB-8814 | biostudies-arrayexpress

SAFA RGG domain in chromatin accessibility regulation

Project description:SAFA RGG domain in chromatin accessibility regulation

| PRJNA821175 | ENA

Regulation of Chromatin Accessibility by hypoxia and HIF_2

Project description:ATAC-seq was performed to investigate changes in chromatin accessibility in repsonse to HIF stabilisation via VH298

2022-03-04 | GSE186123 | GEO