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ABSTRACT: Skin microbiome of Wiskott-Aldrich Syndrome

PROVIDER: PRJNA790974 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17304600_1.fastq.gz	Fastqsanger.gz
	SRR17304600_2.fastq.gz	Fastqsanger.gz
	SRR17304601_1.fastq.gz	Fastqsanger.gz
	SRR17304601_2.fastq.gz	Fastqsanger.gz
	SRR17304602_1.fastq.gz	Fastqsanger.gz

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Next generation sequencing to determine DNA-binding sites of Wiskott-Aldich Syndrome Protein (WASP) in the cell line GM 11518 (wild-type) and in the cell line ID00003/WASP-c-EOS (WASP overexpressed)

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Project description:<p>The NIH Intramural Skin Microbiome Consortium (NISMC) is a collaboration of investigators with primary expertise in genomics, bioinformatics, large-scale DNA sequencing, dermatology, immunology, allergy, infectious disease, and clinical microbiology. Atopic dermatitis (AD, "eczema") is a chronic relapsing skin disorder that affects ~15% of U.S. children and is associated with $1 billion of medical costs annually. AD is characterized by dry, itchy skin, infiltrated with immune cells. Colonization by Staphylococcus aureus (S. aureus) is ten-fold more common in AD patients and is associated with disease flares. We hypothesize that, in addition to S. aureus, AD may also be associated with additional novel microbes and/or selective shifts of commensal microbes that are relevant to disease progression. The NISMC seeks to define the microbiota that resides in and on the skin and nares of three patient groups, all of whom have eczematous lesions and are currently seen at the NIH Clinical Center: (1) AD patients; (2) Wiskott-Aldrich syndrome (WAS) patients; and (3) Hyper IgE syndrome (HIES) syndrome patients. Examination of the microbiome of patients with WAS or HIES syndromes, both rare immunodeficiencies, will advance our understanding of how an individual's immune system shapes their cutaneous microbial community. We are performing a prospective longitudinal study that follows these groups of patient thorough the cycles of eczema flares, ascertaining clinical data and samples at each stage.</p>

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Project description:This experiment intended to define differential gene expression between germinal center B cells expressing or not the Wiskott-Aldrich syndrome protein in mice. Sequencing was obtained on an Illumina HiSeq2500 system from Dark Zone GCB (DAPI-CD19+ GL7+IgD-CXCR4highCD86low) purified from CTL and GCBcWKO mice (n=4).

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