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RNA-Seq analysis of human granulosa cell after COS and mild ovarian stimulation

ABSTRACT: RNA-Seq analysis of human granulosa cell after COS and mild ovarian stimulation

PROVIDER: PRJNA790975 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17282441_1.fastq.gz	Fastqsanger.gz
	SRR17282441_2.fastq.gz	Fastqsanger.gz
	SRR17282442_1.fastq.gz	Fastqsanger.gz
	SRR17282442_2.fastq.gz	Fastqsanger.gz
	SRR17282443_1.fastq.gz	Fastqsanger.gz

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RNA-Seq analysis of human granulosa cell after COS and mild ovarian stimulation

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Project description:The Forkhead Box, FOXO1 and FOXO3, transcription factors regulate multiple functions in mammalian cells. Selective inactivation of the Foxo1 and Foxo3 genes in murine ovarian granulosa cells severely impairs follicular development and apoptosis causing infertility, and as shown herein, granulosa cell tumor (GCT) formation. Coordinate depletion of the tumor suppressor Pten gene in the Foxo1/3 strain enhanced the penetrance and onset of GCT formation A direct comparison of ovarian granulosa cells from wild type d25 and FOXO/PTEN knockout granulosa cell tumors.

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