Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effects of the SLICK1 mutation in PRLR on regulation of core body temperature and global gene expression in liver in cattle

ABSTRACT: Effects of the SLICK1 mutation in PRLR on regulation of core body temperature and global gene expression in liver in cattle

PROVIDER: PRJNA791623 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR17311900_1.fastq.gz	Fastqsanger.gz
	SRR17311900_2.fastq.gz	Fastqsanger.gz
	SRR17311901_1.fastq.gz	Fastqsanger.gz
	SRR17311901_2.fastq.gz	Fastqsanger.gz
	SRR17311902_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 68

Similar Datasets

Effects of the SLICK1 mutation in PRLR on regulation of core body temperature and global gene expression in liver in cattle

Project description:Determine the effect of 0,1, or 2 copies of the slick mutation in the PRLR on gene expression

2022-01-04 | GSE192471 | GEO

PrlR regulon in Brucella melitensis 16M

Project description:Investigation of whole genome gene expression level changes in a Brucella melitensis delta prlr mutant compared to the wild type strain. The mutants analyzed in this study are further described in A. Mirabella, R-M Yanez, R.M. Delrue, S. Uzureau, M.S. Zygmunt, A. Cloeckaert, X. De Bolle, J.J. Letesson (2012). The two component system PrlS/PrlR of Brucella melitensis is required for persistence in mice and appears to respond to ionic strength. Microbiology A six chip study using total RNA recovered from three separate wild-type cultures of Brucella melitensis 16M and three separate cultures of a prlR mutant strain. Each chip measures the expression level of 3,198 genes from Brucella melitensis 16M with nineteen 60 mer probe pairs (PM/MM) per gene, with three-fold technical redundancy.

2012-12-31 | E-GEOD-34633 | biostudies-arrayexpress

PrlR regulon in Brucella melitensis 16M

2012-12-31 | GSE34633 | GEO

Effect of intraoperative temperature management on postoperative myocardial injury in patients with colorectal tumors

Project description:Interventions: aggressively warmed group:Core body temperature was maintained at 37 to 37.5 ° C;actively warmed group:Core body temperature was maintained at 36 to 36.5 ° C;routine thermal management group:Core body temperature was maintained at least 35 ° C Primary outcome(s): troponin I;core body temperature Study Design: Parallel

| 84514 | ecrin-mdr-crc

MiRNA microarray of overexpression Ctrl and PRLR AsPC-1 cells.

Project description:The study is to explore differentially expressed miRNAs in AsPC-1 cells overexpressing Ctrl or PRLR.

2022-10-14 | GSE215273 | GEO

Natural and molecular history of prolactinoma: insights from a Prlr -/- mouse model

Project description:Mouse models of prolactinoma can be useful to better understand molecular mechanisms involved in abnormal lactotroph cell proliferation and secretion. We have previously developed a prolactin receptor deficient (Prlr -/-) mouse, in which Prlr -/- females develop large secreting prolactinomas from 12 months of age with a penetrance of 100%, mimicking human aggressive densely granulated macroprolactinoma, a highly secreting subtype.

2018-02-21 | GSE100334 | GEO

Expression data from islets of non-pregnant and pregnant PRLR+/+ and PRLR-/- mice

Project description:ABSTRACT:Pregnancy requires a higher functional beta cell mass and this is associated with profound changes in the gene expression profile of pancreatic islets. Taking Tph1 as a sensitive marker for pregnancy-related islet mRNA expression in female mice, we previously identified prolactin receptors and placental lactogen as key signalling molecules. Since beta cells from male mice also express prolactin receptors, the question arose whether male and female islets have the same phenotypic resilience at the mRNA level during pregnancy. We addressed this question in vitro, by using islet tissue culture with placental lactogen and in vivo, by transplanting male or female islets into female acceptor mice. Additionally, the islet mRNA expression of pregnant prolactin receptor deficient mice was compared with that of their pregnant wild-type littermates. When cultured with placental lactogen, or transplanted in female recipients that became pregnant (day 12.5), male islets induced the ‘islet pregnancy gene signature’, which we defined as the 12 highest induced genes in non-transplanted female islets at day 12.5 of pregnancy. In addition, serotonin immunoreactivity was also induced in these male transplanted islets at day 12.5 of pregnancy. In order to investigate the importance of prolactin receptors in these mRNA changes we used a prolactin receptor deficient mouse model. For the 12 genes of the signature, which are highly induced in control pregnant mice, no significant induction of mRNA transcripts was found at day 9.5 of pregnancy. Together, our results support the key role of placental lactogen as a circulating factor that can trigger the pregnancy mRNA profile in male and female beta cells. Islets were isolated from non-prengant (NP) and pregnant (day 9.5) PRLR+/+ and PRLR-/- mice for RNA extraction and hybridization on Affymetrix microarrays. For every condition 3 biological replicates were used.

2015-03-31 | E-GEOD-59141 | biostudies-arrayexpress

Genome-wide expression analysis of overexpressing Ctrl and PRLR-SF AsPC-1 cells

Project description:The study is to explore differentially expressed genes in AsPC-1 cells overexpressing Ctrl or PRLR-SF.

2020-10-24 | GSE159917 | GEO

Genome-wide expression analysis of sh-Ctrl and sh-PRLR SW-1990 cells

Project description:The study is to explore differentially expressed genes in SW-1990 cells infected with sh-Ctrl or sh-PRLR.

2020-09-13 | GSE146951 | GEO

A conserved kinase-based body temperature sensor globally controls alternative splicing and gene expression

Project description:Homoeothermic organisms maintain their core body temperature in a narrow, tightly controlled range. Whether and how subtle circadian oscillations or disease-associated changes in core body temperature are sensed and integrated in gene expression programs remains elusive. Furthermore, a thermo-sensor capable of sensing the small temperature differentials leading to temperature-dependent sex determination (TSD) in poikilothermic reptiles has not been identified. Here we show that the activity of CDC-like kinases (CLKs) is highly responsive to physiological temperature changes, which is conferred by structural rearrangements within the kinase activation segment. Lower body temperature activates CLKs resulting in strongly increased phosphorylation of SR-proteins in vitro and in vivo. This globally controls temperature-dependent alternative splicing and gene expression, with wide implications in circadian, tissue-specific and disease-associated settings. This temperature sensor is conserved across evolution and adapted to growth temperatures of diverse poikilotherms. The dynamic temperature range of reptilian CLK homologs suggests a role in TSD.

2020-02-14 | GSE143872 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data