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Neonatal murine cardiomyocyte transcriptome

ABSTRACT: Neonatal murine cardiomyocyte transcriptome

PROVIDER: PRJNA795099 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17464380.fastq.gz	Fastqsanger.gz
	SRR17464381.fastq.gz	Fastqsanger.gz
	SRR17464382.fastq.gz	Fastqsanger.gz
	SRR17464383.fastq.gz	Fastqsanger.gz
	SRR17464384.fastq.gz	Fastqsanger.gz

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Neonatal murine cardiomyocyte transcriptome

Project description:Cardiomyocyte poly(A) RNA was sequenced from purified bulk cardiomyocytes collected from one male and female murine heart at postnatal day 2 (P2). Neonatal cardiomyocytes were isolated and purified (96% cardiomyocytes at P2) by Langendorff retrograde perfusion and immunomagnetic cell separation, respectively. We found evidence of sexual dimorphism with 9 differentially expressed genes (FDR<0.05) encoded on XY chromosomes in this RNA-Seq dataset.

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Project description:Cardiac maturation lays the foundation for postnatal heart development and disease, yet little is known about the contributions of the microenvironment to cardiomyocyte maturation. By integrating single-cell RNA-sequencing data of mouse hearts at multiple postnatal stages, we construct cellular interactomes and regulatory signaling networks. Here we report switching of fibroblast subtypes from a neonatal to adult state and this drives cardiomyocyte maturation. Molecular and functional maturation of neonatal mouse cardiomyocytes and human embryonic stem cell-derived cardiomyocytes are considerably enhanced upon coculture with corresponding adult cardiac fibroblasts. Further, single-cell analysis of in vivo and in vitro cardiomyocyte maturation trajectories identify highly conserved signaling pathways, pharmacological targeting of which substantially delays cardiomyocyte maturation in postnatal hearts, and markedly enhances cardiomyocyte proliferation and improves cardiac function in infarcted hearts. Together, we identify cardiac fibroblasts as a key constituent in the microenvironment promoting cardiomyocyte maturation, providing insights into how the manipulation of cardiomyocyte maturity may impact on disease development and regeneration.

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Project description:Infected neonatal mouse cardiomyocyte; COMMENT: Submitter has not provided GEO with full dataset as described in Nat Genet. 2004 Feb;36(2):123-30.

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Single cell analysis of murine fibroblasts identifies neonatal to adult switching that regulates cardiomyocyte maturation

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