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Genome wide analsis of the chromatin accessibility and gene expression in control and NUDT5 depleted U2OS cells [RNA-seq]

ABSTRACT: Genome wide analsis of the chromatin accessibility and gene expression in control and NUDT5 depleted U2OS cells [RNA-seq]

PROVIDER: PRJNA806965 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18021533_1.fastq.gz	Fastqsanger.gz
	SRR18021533_2.fastq.gz	Fastqsanger.gz
	SRR18021534_1.fastq.gz	Fastqsanger.gz
	SRR18021534_2.fastq.gz	Fastqsanger.gz
	SRR18021535_1.fastq.gz	Fastqsanger.gz

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Genome wide analsis of the chromatin accessibility and gene expression in control and NUDT5 depleted U2OS cells

Project description:NUDT5 was reported to generate ATP to support local chromatin remodeling and transcription of hormone-responsive genes. Our research has found that NUDT5 is also required for DNA damage repair by homologous recombination. To investigate how NUDT5 regulates HR, we depleted NUDT5 in U2OS cells by siRNA and compared the transcriptome profiling (RNA-seq) of NUDT5 depleted cells with control cells to investigate whether NUDT5 regulate HR by altering the expression of essential components of the HR machinery. The results suggest that NUDT5 does not regulate HR by altering the expression of essential components of the HR machinery. To investigate whether NUDT5 contributes to chromatin remodeling after DNA damage, we compared the chromatin accessibility profiling (ATAC-seq) in NUDT5 depleted U2OS cells and control cells, either before or after ionizing radiation. The results suggest that NUDT5 silencing blocked most DNA damage-induced changes in chromatin accessibility following radiation exposure and implies that NUDT5 may support the activity of remodeling ATPases during damage repair.

2023-02-14 | GSE196718 | GEO

Genome wide analsis of the chromatin accessibility and gene expression in control and NUDT5 depleted U2OS cells [RNA-seq]

2023-02-14 | GSE196722 | GEO

Genome wide analsis of the chromatin accessibility and gene expression in control and NUDT5 depleted U2OS cells [ATAC-seq]

2023-02-14 | GSE196721 | GEO

Genome wide analsis of the chromatin accessibility and gene expression in control and NUDT5 depleted U2OS cells

Project description:Genome wide analsis of the chromatin accessibility and gene expression in control and NUDT5 depleted U2OS cells

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Genome wide analsis of the chromatin accessibility and gene expression in control and NUDT5 depleted U2OS cells [ATAC-seq]

Project description:Genome wide analsis of the chromatin accessibility and gene expression in control and NUDT5 depleted U2OS cells [ATAC-seq]

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ChIP-seq mapping of gH2AX, PanKcr, H3K9cr, and ENL at AsiSI-induced double-strand breaks in control and CDYL1-depleted U2OS-DIvA cells

Project description:Control and CDYL1-depleted U2OS-DIvA cells were treated with 4-hydroxy tamoxifen (4OHT) to induce multiple DNA double-strand breaks (DSBs) at defined loci in the genome via AsiSI restriction enzyme. This system was used to map the changes in lysine crotonylation (Kcr) and ENL at DSB sites in control and CDYL1-deficient cells.

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Project description:RNA-seq of human U2OS cells depleted of NUAK1 by shRNA compared to control

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Project description:Aim: To determine the impact of NUAK1 depletion on the transcriptome of U2OS cells.

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U2OS-ERa, U2OS-ERb, and U2OS-ERab cells treated with 4HT or E2

Project description:U2OS-ERa, U2OS-ERb, and U2OS-ERab cells treated with 4HT or E2 Keywords: other