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Polymer-coated gold nanoparticles target Age-Associated B cells in vivo

ABSTRACT: Polymer-coated gold nanoparticles target Age-Associated B cells in vivo

PROVIDER: PRJNA812915 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18230061.fastq.gz	Fastqsanger.gz
	SRR18230062.fastq.gz	Fastqsanger.gz
	SRR18230063.fastq.gz	Fastqsanger.gz
	SRR18230064.fastq.gz	Fastqsanger.gz
	SRR18230065.fastq.gz	Fastqsanger.gz

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Polymer-coated gold nanoparticles target Age-Associated B cells in vivo

Project description:Engineered gold nanoparticles (GNPs) have become a useful tool in various therapeutic and diagnostic applications. Uncertainty remains regarding possible impacts of GNPs to the immune system. In this regard, we investigated the interactions of polymer-coated GNPs with B cells and their functions in mice as they constitute a crucial part of the immune system and represent a potential target for systemically administered GNPs. Surprisingly, we observed that polymer-coated GNPs mainly interact with the recently identified subpopulation of B lymphocytes named Age-associated B cells (ABCs). Importantly, we also showed that GNPs did not affect the percentages of other B cell populations in different organs. Furthermore, GNPs did not activate B cell innate-like immune responses in any of the tested conditions, nor did they impair adaptive B cell responses in immunized mice. Together, these data provide an important contribution to otherwise limited knowledge about GNP interference with B cell immune function, and demonstrate that GNPs represent a safe tool to target ABCs in vivo for various potential applications.

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