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A low sugar diet enhances Drosophila body size in males and females via sex-specific mechanisms

ABSTRACT: A low sugar diet enhances Drosophila body size in males and females via sex-specific mechanisms

PROVIDER: PRJNA815294 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18301712_1.fastq.gz	Fastqsanger.gz
	SRR18301712_2.fastq.gz	Fastqsanger.gz
	SRR18301713_1.fastq.gz	Fastqsanger.gz
	SRR18301713_2.fastq.gz	Fastqsanger.gz
	SRR18301714_1.fastq.gz	Fastqsanger.gz

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A low sugar diet enhances Drosophila body size in males and females via sex-specific mechanisms

Project description:We report sex differences in mRNA levels between male and female Drosophila larvae reared on a diet containing sugar (1S) vs a -low-sugar diet (0S)

2022-03-14 | GSE198435 | GEO

A low-sugar diet enhances Drosophila body size in males and females via sex-specific mechanisms.

Project description:In Drosophila, changes to dietary protein elicit different body size responses between the sexes. Whether these differential body size effects extend to other macronutrients remains unclear. Here, we show that lowering dietary sugar (0S diet) enhanced body size in male and female larvae. Despite an equivalent phenotypic effect between the sexes, we detected sex-specific changes to signalling pathways, transcription and whole-body glycogen and protein. In males, the low-sugar diet augmented insulin/insulin-like growth factor signalling pathway (IIS) activity by increasing insulin sensitivity, where increased IIS was required for male metabolic and body size responses in 0S. In females reared on low sugar, IIS activity and insulin sensitivity were unaffected, and IIS function did not fully account for metabolic and body size responses. Instead, we identified a female-biased requirement for the Target of rapamycin pathway in regulating metabolic and body size responses. Together, our data suggest the mechanisms underlying the low-sugar-induced increase in body size are not fully shared between the sexes, highlighting the importance of including males and females in larval studies even when similar phenotypic outcomes are observed.

| S-EPMC10656461 | biostudies-literature

Eucommia ulmoides strain:males and females

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Project description:In the present study we compare the secretome from S. mansoni adult males and females using a label free quantitative proteomic approach

2022-06-07 | PXD030699 | Pride

Transcription profiling of Drosophila abdomen from females mated with sex peptide null or sex peptide producing males

Project description:Comparison of females mated to males null for Sex-Peptide (SP0, Liu, H. and E. Kubli, Sex-peptide is the molecular basis of the sperm effect in Drosophila melanogaster. Proc Natl Acad Sci U S A, 2003. 100(17): p. 9929-33) or to control, Sex-Peptide producing, males. Comparisons were made at 3 and 6 hours after mating, in dissected Abdomen parts.<br>

2009-08-01 | E-MEXP-2074 | biostudies-arrayexpress

MicroRNA profiling of Drosophila abdomen from females mated with sex peptide null or sex peptide producing males

2009-08-01 | E-MEXP-2080 | biostudies-arrayexpress

Muscle function in fit and (pre-)frail males and females

Project description:AbstractBackground: A decreased intramuscular carnitine status with aging may contribute to frailty and fatigue, but studies are often confounded by sex-heterogeneity and lack of control groups. We hypothesize that muscle carnitine deficiency is associated with (pre-)frailty, diminished physical performance and altered mitochondrial function, possibly in a sex-dependent manner. This was tested in well-matched age groups, allowing gender-specific analyses. Methods: A cross-sectional study was performed in well-matched fit (n = 15) and (pre-)frail (n = 13) old males as well as in fit (n = 15) and (pre-)frail (n = 11) old females, using young males (n = 13) and females (n = 13) as healthy controls. In the elderly, frailty was assessed according to the Fried criteria and physical performance was determined by 400-m walk test, short physical performance battery and handgrip strength. Acylcarnitine status was assessed in muscle biopsies and blood plasma using liquid chromatography-tandem mass spectrometry. Muscle mitochondrial gene expression was analyzed. Results: Intramuscular total carnitine levels and short chain acylcarnitine levels were lower in (pre-)frail old females compared to fit old females and young females, whereas no differences were observed in males. Intramuscular short chain acylcarnitine levels were associated with low physical performance in females, even after correction for muscle mass (%), whereas in males no such association was found. The decline in short chain acylcarnitine levels in (pre-)frail old females was associated with low expression of genes involved in mitochondrial energy production and mitochondrial functionality. Conclusions: In (pre-)frail old females, intramuscular total carnitine levels and short chain acylcarnitine levels are decreased and this decrease is accompanied by reduced physical performance and low expression of a wide range of genes involved in mitochondrial function.

2023-02-04 | GSE144304 | GEO

MicroRNA profiling of Drosophila head and thorax from females mated with sex peptide null or sex peptide producing males

2009-08-01 | E-MEXP-2079 | biostudies-arrayexpress

Transcription profiling by array of Drosophila head and thorax from females mated with sex peptide null or sex peptide producing males

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Project description:The nematode Auanema rhodensis is trioecious (co-occurrence of males, females and self-fertile hermaphrodites). To better understand its sex determination system, we have compared the transcriptomic profiles of early (L2) females, hermaphrodites and converted females (hermaphrodite-fated larvae induced to develop as females). Additionally, we sequenced the transcriptome of adult males and individuals from various stages and sexes (mixed stages samples) to compare global gene expression profiles along the assembled draft chromosomes of A. rhodensis (BioProject PRJEB29492). The RNA-seq data was also used to predict genes in the assembled genome. We generated three biological replicates for each RNA-seq condition (L2 females, L2 converted females, L2 hermaphrodites, males and mixed stages). Comparisons of the expression profiles of the L2 conditions was performed to identify genes potentially involved in the sexual differentiation process, using a standard RNA-seq comparison approach. Briefly, the cleaned reads were aligned to the genome using STAR, the abundance and identification of differentially expressed genes were assessed using FeatureCounts and DEseq2 (using as thresholds an absolute log2(Fold Change) >= 2 and an FDR <0.01).

2019-02-11 | E-MTAB-7667 | biostudies-arrayexpress

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