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ABSTRACT: The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract

PROVIDER: PRJNA818732 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18467431.fastq.gz	Fastqsanger.gz
	SRR18467432.fastq.gz	Fastqsanger.gz
	SRR18467433.fastq.gz	Fastqsanger.gz
	SRR18467434.fastq.gz	Fastqsanger.gz
	SRR18467435.fastq.gz	Fastqsanger.gz

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The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract

Project description:The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract

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Project description:The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract [Affymetrix]

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The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract [NimbleGen]

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The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract [methylation]

Project description:The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract [methylation]

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The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract [ChIP-Seq]

Project description:The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract [ChIP-Seq]

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Transcription profiling of Drosophila Hr39 mutant females reveals the sf1-related nuclear hormone receptor hr39 regulates Drosophila female reproductive tract development and function

Project description:The vertebrate nuclear hormone receptor steroidogenic factor 1 (SF1; NR5A1) controls reproductive development and regulates the transcription of steroid-modifying cytochrome P450 genes. We find that the SF1-related Drosophila nuclear hormone receptor HR39 is also essential for sexual development. In Hr39 mutant females, the sperm-storing spermathecae and glandular parovaria are absent or defective, causing sterility. Our results indicate that spermathecae and parovaria secrete reproductive tract proteins required for sperm maturation and function, like the mammalian epididymis and female reproductive tract. Hr39 controls the expression of specific cytochrome P450 genes and is required in females both to activate spermathecal secretion and repress male-specific courtship genes such as takeout. Thus, a pathway that, in vertebrates, controls sex-specific steroid hormone production, also mediates reproductive functions in an invertebrate. Our findings suggest that Drosophila can be used to model more aspects of mammalian reproductive biology than previously believed. Experiment Overall Design: Wild type and Hr39(04443) Spermathecae, Wild type and Hr39(04443) Reproductive Tract

2008-06-11 | E-GEOD-10264 | biostudies-arrayexpress

Project description:The vertebrate nuclear hormone receptor steroidogenic factor 1 (SF1; NR5A1) controls reproductive development and regulates the transcription of steroid-modifying cytochrome P450 genes. We find that the SF1-related Drosophila nuclear hormone receptor HR39 is also essential for sexual development. In Hr39 mutant females, the sperm-storing spermathecae and glandular parovaria are absent or defective, causing sterility. Our results indicate that spermathecae and parovaria secrete reproductive tract proteins required for sperm maturation and function, like the mammalian epididymis and female reproductive tract. Hr39 controls the expression of specific cytochrome P450 genes and is required in females both to activate spermathecal secretion and repress male-specific courtship genes such as takeout. Thus, a pathway that, in vertebrates, controls sex-specific steroid hormone production, also mediates reproductive functions in an invertebrate. Our findings suggest that Drosophila can be used to model more aspects of mammalian reproductive biology than previously believed. Keywords: mutant/wild-type comparison and tissue comparison

2008-04-26 | GSE10264 | GEO

The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract [Affymetrix]

Project description:We identify an unexpected functional role for E3 in fetal reproductive system and brain. We further identify a novel mechanism of estrogen action, through recruitment of epigenetic modifiers to estrogen receptors and their target genes, which doesn’t correlated with the traditional view of estrogen potency.

2023-03-23 | GSE199174 | GEO