Expression data of pig pancreas from Oncopig tumor and normal pigs
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA838007 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:In order to determine the difference in expression between pancreatic tumors generated from OCM or Oncopigs and wild type pig pancreas, we have harvested pancreatic tumors and normal pancreas from two OCM subjects and two normal pigs, respectively.
2022-05-17 | GSE203011 | GEO
Project description:Skin & Pancreas chronic inflammation versus Normal Skin & Pancreas
| PRJNA857740 | ENA
Project description:Acute pancreatitis (AP) is acute inflammation of the pancreas, mainly caused by gallstones and alcohol, driven by changes in communication between cells. Heparin-binding proteins (HBPs) play a central role in cell communication. Therefore, we used heparin affinity proteomics to identify extracellular HBPs in pancreas and plasma of normal mice and in a caerulein mouse model of AP. Many new extracellular HBPs (360) were discovered in the pancreas, taking the total number of HBPs known to 786. Extracellular pancreas HBPs form highly interconnected protein-protein interaction networks in both normal pancreas (NP) and AP. Thus, HBPs represent an important set of extracellular proteins with significant regulatory potential in the pancreas. HBPs in NP are associated with biological functions such as molecular transport and cellular movement that underlie pancreatic homeostasis. However, in AP HBPs are associated with additional processes such as acute phase response signalling, complement activation and mitochondrial dysfunction. Plasma HBPs in AP included known AP biomarkers such as serum amyloid A, as well as emerging targets such as histone H2A. Pancreas HBPs are extracellular and so easily accessible and are potential drug targets in AP, whereas plasma HBPs represent potential biomarkers for AP.
2018-12-17 | PXD012039 | Pride
Project description:To find which signaling is activated in chronic inflammation, we tried to induce chronic skin and pancreas inflammation compared to normal skin and pancreas.
2024-03-01 | GSE207956 | GEO
Project description:Since CNVs play a vital role in genomic studies, it is an imperative need to develop a comprehensive, more accurate and higher resolution porcine CNV map with practical significance in follow-up CNV functional analyses To detect CNV of pigs, we performed high density aCGH data of diverse pig breeds in the framework of the pig draft genome sequence (Sscrofa10.2) 9 Chinese indigenous pig, one Chinese wild boar and 2 commercial pigs were detected using one pig of Duroc as reference. These 12 animals include 1 wild pig, 2 pigs each from Yorkshire and Landrace as the representatives of modern commercial breeds and 9 unrelated individuals selected from 6 Chinese indigenous breeds (2- Tibetan pig, 2- Diannan small-ear pig, 2-Meishan pig, 1- Min pig, 1-Daweizi pig, and 1-Rongchang pig).
2015-06-29 | E-GEOD-49299 | biostudies-arrayexpress
Project description:Since CNVs play a vital role in genomic studies, it is an imperative need to develop a comprehensive, more accurate and higher resolution porcine CNV map with practical significance in follow-up CNV functional analyses To detect CNV of pigs, we performed high density aCGH data of diverse pig breeds in the framework of the pig draft genome sequence (Sscrofa10.2) 9 Chinese indigenous pig, 2 commercial pigs, 1 wild pig were detected using one pig of Duroc as reference.
2013-05-15 | E-GEOD-46847 | biostudies-arrayexpress
Project description:Microplastics are a relatively newly discovered environmental hazard that can contribute to the disruption of many physiological processes in the organism. There is evidence that they affect the physiology of the pancreas, but research is still very limited. Therefore, the aim of the study was to determine the effects of PET microplastics on the global proteomic profile of the porcine pancreas using LC-MS/MS analysis. The pigs were treated with a low (0.1 g/day) or a high dose (1 g/day) of PET microplastics for 4 weeks. The analysis revealed that PET microplastics affected protein expression in a dose-dependent manner - the low dose affected the abundance of 7 proteins, while the high dose of 17.
2025-07-07 | MSV000098442 | MassIVE
Project description:Pig brains are valuable models for studying brain diseases due to their structural similarities to human brains. However, understanding the regulatory mechanisms in pig brains is challenging due to cellular heterogeneity. This study aimed to investigate the heterogeneity of pig brains and uncover the underlying regulatory mechanisms at single-cell resolution. We created the first single-cell chromatin accessibility atlas of the cerebral cortex and cerebellum in domestic pigs and wild boars using single-cell ATAC-seq (scATAC-seq). We profiled 71,798 cells, identifying nine cell types, and integrated single-cell RNA sequencing (scRNA-seq) data to characterize cell type-specific regulatory landscapes and oligodendrocyte development. Our analysis revealed that oligodendrocyte progenitor cells exhibit the fastest evolutionary rate between domestic pigs and wild boars. Additionally, cross-species comparison showed that pig regulatory elements are more conserved with humans than those in mice. Notably, genetic variant enrichment studies found that regulatory elements associated with Alzheimer’s disease were significantly enriched in pigs but not in mice, suggesting pigs as a potentially superior model for this condition. Conversely, neurological diseases like schizophrenia and bipolar disorder showed higher enrichment in mice.
2025-05-11 | GSE281568 | GEO
Project description:Since CNVs play a vital role in genomic studies, it is an imperative need to develop a comprehensive, more accurate and higher resolution porcine CNV map with practical significance in follow-up CNV functional analyses To detect CNV of pigs, we performed high density aCGH data of diverse pig breeds in the framework of the pig draft genome sequence (Sscrofa10.2)
2013-05-15 | GSE46847 | GEO