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Ribosome protein RPSA promotes the expression of proinflammatory cytokines induced by HSV-1 infection

ABSTRACT: Ribosome protein RPSA promotes the expression of proinflammatory cytokines induced by HSV-1 infection

PROVIDER: PRJNA842685 | ENA |

REPOSITORIES: ENA

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Ribosome protein RPSA promotes the expression of proinflammatory cytokines induced by HSV-1 infection

Project description:After HSV-1 infection, ribosomal protein RPSA can recognize viral DNA. To further verify the biological function of RPSA, we constructed the RPSA-deficient RAW264.7 macrophage cell line with the inducible CRISPR-Cas9 system, then found that the deletion of RPSA could effectively reduce the expression of proinflammatory cytokines such as IL-1α, IL-1β, IL-6, IL-12 and TNFα induced by HSV-1 infection.

2023-11-12 | GSE204893 | GEO

Deficiency of RPSA reduces binding of P65 to proinflammatory cytokines promoter regions in HSV-1 infection

Project description:After HSV-1 infection, ribosomal protein RPSA can recognize viral DNA and promotes the expression of proinflammatory cytokines. Through ChIP-seq, we found that the enrichment of P65 in proinflammatory cytokines(Il1b, Il6, Il12b, etc.) promoter regions was decreased due to Rpsa deficiency.

2023-11-12 | GSE204891 | GEO

RPSA and proinflammatory cytokines after HSV-1 infection

Project description:RPSA and proinflammatory cytokines after HSV-1 infection

| PRJNA842678 | ENA

ATAC-seq analysis in Rpsa-iKO RAW264.7 cells after HSV-1 infection

Project description:After HSV-1 infection, ribosomal protein RPSA can recognize viral DNA and promotes the expression of proinflammatory cytokines. Through ATAC-seq, we found that chromatin accessibility around transcription start sites (TSS) of proinflammatory cytokinse in HSV-1 infected Rpsa-iKO RAW264.7 was significantly reduced

2023-11-12 | GSE204889 | GEO

Deficiency of Rpsa results in reduced levels of H3K4me3 in inflammatory cytokines promoter regions

Project description:After HSV-1 infection, ribosomal protein RPSA can recognize viral DNA and promotes the expression of proinflammatory cytokines. Through ChIP-seq, we found that the level of H3K4me3 in proinflammatory cytokines(Il1b, Il6, Il12b, etc.) promoter regions was decreased due to Rpsa deficiency.

2023-11-12 | GSE204890 | GEO

Deficiency of RPSA reduces binding of P65 to proinflammatory cytokines promoter regions in HSV-1 infection

Project description:Deficiency of RPSA reduces binding of P65 to proinflammatory cytokines promoter regions in HSV-1 infection

| PRJNA842687 | ENA

RPSA and proinflammatory cytokines after HSV-1 infection

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-11-12 | GSE204895 | GEO

ATAC-seq analysis in Rpsa-iKO RAW264.7 cells after HSV-1 infection

Project description:ATAC-seq analysis in Rpsa-iKO RAW264.7 cells after HSV-1 infection

| PRJNA842689 | ENA

Ribosome profiling of HSV-1 infected cells

Project description:Ribosome profiling of HSV-1 infected cells

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Ribosomal Protein SA (RPSA) is required for localized translation and sarcomere maintenance

Project description:Cardiomyocyte sarcomeres contain localized ribosomes, but the factors responsible for their localization and the significance of localized translation are unknown. Using proximity labeling, we identified Ribosomal Protein SA (RPSA) as a Z-line protein. In cultured cardiomyocytes, the loss of RPSA led to impaired local protein translation and reduced sarcomere integrity. By employing CAS9 expression mice along with adeno-associated viruses expressing CRE recombinase and single-guide RNAs targeting Rpsa, we knocked out RPSA in vivo and observed mis-localization of ribosomes and diminished local translation. These genetic mosaic mice with RPSA knockout in a subset of cardiomyocytes developed dilated cardiomyopathy, featuring atrophy of RPSA-deficient cardiomyocytes, compensatory hypertrophy of unaffected cardiomyocytes, left ventricular dilation, and impaired contractile function. We demonstrate that RPSA C-terminal domain is sufficient for localization Z-lines. These findings highlight RPSA as a ribosomal factor responsible for ribosome localization to the Z-line, facilitating local translation and sarcomere maintenance.

2024-06-04 | PXD046385 | Pride

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