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Deficiency of RPSA reduces binding of P65 to proinflammatory cytokines promoter regions in HSV-1 infection

ABSTRACT: Deficiency of RPSA reduces binding of P65 to proinflammatory cytokines promoter regions in HSV-1 infection

PROVIDER: PRJNA842687 | ENA |

REPOSITORIES: ENA

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Deficiency of RPSA reduces binding of P65 to proinflammatory cytokines promoter regions in HSV-1 infection

Project description:After HSV-1 infection, ribosomal protein RPSA can recognize viral DNA and promotes the expression of proinflammatory cytokines. Through ChIP-seq, we found that the enrichment of P65 in proinflammatory cytokines(Il1b, Il6, Il12b, etc.) promoter regions was decreased due to Rpsa deficiency.

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Ribosome protein RPSA promotes the expression of proinflammatory cytokines induced by HSV-1 infection

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Project description:After HSV-1 infection, ribosomal protein RPSA can recognize viral DNA and promotes the expression of proinflammatory cytokines. Through ATAC-seq, we found that chromatin accessibility around transcription start sites (TSS) of proinflammatory cytokinse in HSV-1 infected Rpsa-iKO RAW264.7 was significantly reduced

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RPSA and proinflammatory cytokines after HSV-1 infection

Project description:This SuperSeries is composed of the SubSeries listed below.

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Project description:Deficiency of Rpsa results in reduced levels of H3K4me3 in inflammatory cytokines promoter regions

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