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Brain mural cells differentiated from human pluripotent stem cell-derived neural crest via Notch3 activation

ABSTRACT: Brain mural cells differentiated from human pluripotent stem cell-derived neural crest via Notch3 activation

PROVIDER: PRJNA844098 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19461373_1.fastq.gz	Fastqsanger.gz
	SRR19461373_2.fastq.gz	Fastqsanger.gz
	SRR19461374_1.fastq.gz	Fastqsanger.gz
	SRR19461374_2.fastq.gz	Fastqsanger.gz
	SRR19461375_1.fastq.gz	Fastqsanger.gz

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Notch3 ChIP-sequencing of brain mural cells differentiated from human pluripotent stem cell-derived neural crest via Notch3 activation

Project description:Molecular mechanisms underlying the differentiation of brain mural cells from neural crest are poorly understood. We found that activation of Notch3 signaling in human pluripotent stem cell-derived neural crest (using lentiviral overexpression of the human Notch3 intracellular domain, N3ICD) was sufficient to direct the differentiation of mural cells. We used Notch3 ChIP-sequencing to identify cis-regulatory elements directly bound by the Notch3 transcriptional activation complex in this system.

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Brain mural cells differentiated from human pluripotent stem cell-derived neural crest via Notch3 activation

Project description:This SuperSeries is composed of the SubSeries listed below.

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