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RNA sequencing of LPS-stimulated bone marrow-derived macrophages pre-treated with MB-3 or DMSO

ABSTRACT: RNA sequencing of LPS-stimulated bone marrow-derived macrophages pre-treated with MB-3 or DMSO

PROVIDER: PRJNA844226 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19501159_1.fastq.gz	Fastqsanger.gz
	SRR19501159_2.fastq.gz	Fastqsanger.gz
	SRR19501160_1.fastq.gz	Fastqsanger.gz
	SRR19501160_2.fastq.gz	Fastqsanger.gz
	SRR19501161_1.fastq.gz	Fastqsanger.gz

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RNA sequencing of LPS-stimulated bone marrow-derived macrophages pre-treated with MB-3 or DMSO

Project description:We report the application of RNA sequencing technology for high-throughput profiling in mouse bone marrow-derived macrophages pre-treated with MB-3(50μM) or DMSO, and stimulated with LPS(100ng/ml) for 4 hours. The goal of this study is to search differential gene in indicated groups. Through differential gene analysis, we can find out the specific mechanism of MB-3 inhibits LPS-induced pro-inflammatory gene transcription but promotes the expression of gene involved in NRF2 pathway and anti-oxidation acitivity.

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