Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of depletion of CD38 on gene expression in LPS/IFNg-stimulated primary mouse astrocytes

ABSTRACT: Effect of depletion of CD38 on gene expression in LPS/IFNg-stimulated primary mouse astrocytes

PROVIDER: PRJNA848398 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR19632576_1.fastq.gz	Fastqsanger.gz
	SRR19632576_2.fastq.gz	Fastqsanger.gz
	SRR19632577_1.fastq.gz	Fastqsanger.gz
	SRR19632577_2.fastq.gz	Fastqsanger.gz
	SRR19632578_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 48

Similar Datasets

Effect of depletion of CD38 on gene expression in LPS/IFNg-stimulated primary mouse astrocytes

Project description:To investigate the role of CD38 activity on astrocyte pro-inflmmatory activation

2022-08-12 | GSE205943 | GEO

Effect of NAMPT inhibition on gene expression in LPS/IFNg-stimulated primary mouse astrocytes

Project description:Effect of NAMPT inhibition on gene expression in LPS/IFNg-stimulated primary mouse astrocytes

| PRJNA848397 | ENA

Postnatal expression of CD38 in astrocytes regulates synapse formation and adult social memory

Project description:To investigate effect of CD38 knockout on gene expression in astrocytes, we performed RNA-seq of WT and CD38 KO primary astrocytes.

2023-05-17 | GSE216887 | GEO

Emodin inhibits macrophage classical activation [Control-LPS-IFNg-Emodin]

Project description:In order to fully characterize emodin's effects on macrophage activation, peritoneal macrophages were stimulated with LPS+IFNg with or without emodin and gene expression was analyzed using a whole genome microarray. Emodin significantly attenuated the IFNg/LPS induced changes in a large percentage of responsive genes (31%) through inhibiting multiple signaling pathways. RT-qPCR was used to confirm the results in several genes associated with M1 macrophage activation including: TNF, IL6, IL1b, iNOS, MMP2, and MMP9. Three-condition, one-color experiment: Vehicle control, LPS-IFNg or LPS-IFNg-Emodin treated periferal WBC PMN samples: 4 biological replicates each.

2016-07-04 | E-GEOD-73310 | biostudies-arrayexpress

Emodin inhibits macrophage classical activation [Control-LPS-IFNg-Emodin]

2016-01-02 | GSE73310 | GEO

LPS and IFNg stimulated mouse airways

Project description:Transcription profiling by array was performed on airway wall samples from PBS, LPS, IFN-gamma and LPS+IFN-gamma treated BALB/c mice 12 hr post treatments.

2015-10-13 | E-MTAB-1893 | biostudies-arrayexpress

RNA-seq analysis of functionally distinct HLADR+CD38+ CD8 T cells from acute dengue febrile patients

Project description:A discrete population of the CD8 T population with HLADR+ CD38+ phenotype expand massively during the acute febrile phase of natural infection with dengue virus. Although about a third of these massively expanding HLADR+ CD38+ CD8 T cells were also CD69high when examined ex vivo, only a small fraction made IFNg upon in vitro peptide stimulation. Here we analyse the transcriptional profile of CD69+IFNg+, CD69+IFNg-, CD69-IFNg-, unstimulated HLADR+ CD38+ and HLADR-CD38- subsets upon peptide stimulation using RNA seq.

2023-09-22 | GSE212034 | GEO

Effect of LPS-MCM and Hemin-MCM on gene expression of astrocytes

Project description:To investigate the transcriptional changes occurred in astrocytes after inflammatory or hemorrhagic stroke in vitro, we performed RNA sequencing (RNA-seq) of resting-MCM treated astrocytes, LPS-MCM treated astrocytes, and Hemin-MCM treated astrocytes.

2024-06-20 | GSE228927 | GEO

Human neutrophils stimulated with IFNg.

Project description:Human neutrophils stimulated with IFNg.

| PRJNA558805 | ENA

RNA-seq of non-LPS treated (N), non-tolerized (NT), and tolerized (T) IFNg-primed macrophages pretreated with or without HDAC3i

Project description:In this experiment we investigated the effect of HDAC3 inhibition on the transcriptome of IFNg-primed macrophages under different tolerization conditions. Peripheral blood mononuclear cells (PBMCs) were isolated from 3 healthy donors. PBMCs were isolated from whole blood of healthy donors using Ficoll gradient (Invitrogen). Monocytes (CD14+ cells) were positively selected from PBMCs using CD14 Microbeads according to the manufacturer’s instructions (Miltenyi Biotec). Monocytes were subsequently treated with or without 500 nM HDAC3i (ITF3100) for 30 minutes prior to overnight IFNg priming (50 ng/mL). Cells were then kept without LPS (non-LPS; N), treated with 10 ng/mL LPS once (non-tolerized; NT), or treated with LPS twice (tolerized; T; second LPS concentration: 100 ng/mL).

2020-02-12 | E-MTAB-8784 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data