Project description:Superenhancers drive abnormal gene expression in tumors and promote malignancy. However, the relationship between superenhancer-associated lncRNA and abnormal metabolism is unknown.
Project description:Superenhancers drive abnormal gene expression in tumors and promote malignancy. However, the relationship between superenhancer-associated lncRNA and abnormal metabolism is unknown.
Project description:LncRNA profiling of hepatocellular carcinoma vs. matched noncancerous liver tissue, aimed to analyze the lncRNA expression profile of hepatocellular carcinoma (HCC) and identify prognosis-related lncRNAs.
Project description:To explore critical roles of lncRNA and mRNA playing in the pathogenesis of hepatocellular carcinoma, the Agilent microarray was used to simultaneously profile lncRNA and mRNA expression in 7 pairs of HCC and matched adjacent tumor-free tissues.
Project description:Sulfatide significantly promoted hepatocellular carcinoma cells survival, proliferation and angiogenesis. To understand the molecular mechanisms of sulfatide, the transcriptional profiles of lncRNAs in human hepatocellular carcinoma cells SMMC-7721 was investigated with ArrayStar lncRNA microarray with sulfatide treatment. Galactose-cerebroside treatment served as the control.
Project description:We conducted an RNA pulldown assay in Hepatocellular carcinoma cell line HepG2 using in vitro-transcribed full-length LINC01186 RNA accompanied with a control EGFP RNA. The specific binding proteins of LINC01186 was identified using high-performance liquid chromatography-mass spectrometry (HPLC-MS).