Project description:Superenhancers drive abnormal gene expression in tumors and promote malignancy. However, the relationship between superenhancer-associated lncRNA and abnormal metabolism is unknown.
Project description:Superenhancers drive abnormal gene expression in tumors and promote malignancy. However, the relationship between superenhancer-associated lncRNA and abnormal metabolism is unknown.
Project description:LncRNA profiling of hepatocellular carcinoma vs. matched noncancerous liver tissue, aimed to analyze the lncRNA expression profile of hepatocellular carcinoma (HCC) and identify prognosis-related lncRNAs.
Project description:To explore critical roles of lncRNA and mRNA playing in the pathogenesis of hepatocellular carcinoma, the Agilent microarray was used to simultaneously profile lncRNA and mRNA expression in 7 pairs of HCC and matched adjacent tumor-free tissues.
Project description:Sulfatide significantly promoted hepatocellular carcinoma cells survival, proliferation and angiogenesis. To understand the molecular mechanisms of sulfatide, the transcriptional profiles of lncRNAs in human hepatocellular carcinoma cells SMMC-7721 was investigated with ArrayStar lncRNA microarray with sulfatide treatment. Galactose-cerebroside treatment served as the control.
Project description:LncRNA and mRNA expression profiling of Hepatocellular carcinoma Huh7 when HINT1 knockdown. HINT1 is a novel tumor suppressor gene, which can regulate the transcription of a variety of cancer-related genes, and its regulation networks is poorly understood in hepatocellular carcinoma. We used the total RNA from siControl and siHINT1 Huh7 cells to analyze the differentially expressed lncRNA and mRNA which were regulated by HINT1, and further explored the ceRNA network that HINT1 may involved.