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Homo sapiens cultivar:dermal papilla cell

ABSTRACT: Effect of Schizochytrium sp. extracted lipids on dermal papilla cells

PROVIDER: PRJNA859644 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR20999535_1.fastq.gz	Fastqsanger.gz
	SRR20999535_2.fastq.gz	Fastqsanger.gz
	SRR20999536_1.fastq.gz	Fastqsanger.gz
	SRR20999536_2.fastq.gz	Fastqsanger.gz
	SRR20999537_1.fastq.gz	Fastqsanger.gz

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Expression data of human dermal papilla cell with or without beta-estradiol

Project description:The dermal papilla plays a key role in the regulation of the hair biology. Accordingly, human dermal papilla cells (hDPCs) may be functionally impaired in female pattern hair loss. A previous observation that beta-estradiol (E2) increased hair density in ovariectomized mice suggested that E2 might modulate the biological properties of hDPCs. Therefore, to further explore the effect of E2 on hDPCs, a global gene expression analysis was conducted.

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Project description:Different types of hair follicles can be found in the skin of mice. It is believed that the signals that control hair follicle differentiation arise from cells in a structure called the dermal papilla. Understanding the nature of those signals is of interest for the biology of the normal tissue. We have developed a technique for isolation of dermal cells by enzymatic digestion of intact skin. We have identified two subpopulations of cells that can be separated by FACS. The Sox2-positive CD133-positive cells are found exclusively in the dermal papillae of guard/awl/auchene hairs, while Sox2-negative, CD133-positive cells are found in the other hair follicle types. We compared these populations with unfractionated dermal cells. We isolated the following 3 populations of cells from the back skin of neonatal mice (P2) by Flow Cytometry: 1) GFP-CD133- Total dermal cells 2) GFP-CD133+ Dermal Papilla cells 3) GFP+CD133+ Dermal Papilla cells The yield is approximately 50,000 cells of each population.

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