Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of Rab35 knockdown on in vitro differentiated hepatocyte gene expression (time-course)

ABSTRACT: Effect of Rab35 knockdown on in vitro differentiated hepatocyte gene expression (time-course)

PROVIDER: PRJNA862855 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Effect of Rab35 knockdown on in vitro differentiated hepatocyte gene expression (time-course)

Project description:Rab35 knockdown results in a loss of apical bulkheads from hepatocytes, which causes isotropic growth of the bile canaliculus (BC) and ultimately results in the formation of hepatocyte cysts. In these cysts, hepatocytes have common apico-basal polarity, such as observed for simple epithelia like cholangiocytes. To investigate whether this change in polarization is associated with alterations in gene expression we compared hepatocytes with and without Rab35 knockdown in a previous RNA-sequencing experiment and found changes in gene expression after 5 days of culture. In this experiment, we want to investigate when Rab35 knockdown starts to affect gene expression. For this, we performed a time-course RNA-sequencing experiment in hepatocytes with and without Rab35 knockdown.

2024-10-16 | GSE209876 | GEO

Hepatocyte growth factor time course

Project description:Cultured Madin-Darby canine kidney (MDCK) cells treated with hepatocyte growth factor (HGF) for 0, 3 and 24 hours. Each time point in triplicate. Keywords: time-course

2003-11-04 | GSE578 | GEO

Effect of Myh9 knockdown and PEG950 treatment on in vitro differentiated hepatocyte gene expression

Project description:Effect of Myh9 knockdown and PEG950 treatment on in vitro differentiated hepatocyte gene expression

| PRJNA1167646 | ENA

Effect of Myh9 knockdown and PEG950 treatment on in vitro differentiated hepatocyte gene expression

Project description:Myh9 knockdown reduces the strength of the apical actomyosin cortex from hepatocytes, which causes isotropic growth of the bile canaliculus (BC) and ultimately results in the formation of hepatocyte cysts with a large central apical lumen. Treatment of hepatocytes with the osmotically active bioinert polymer PEG950 causes and increase in intraluminal pressure, which causes expansion of the bile canaliculus (BC) and ultimately results in the formation of hepatocyte cysts with a large central apical lumen. In these cysts, hepatocytes have common apico-basal polarity, such as observed for simple epithelia like cholangiocytes. To investigate whether this change in apical lumen morphology and polarization is associated with alterations in gene expression we compared hepatocytes with and without Myh9 knockdown and with and without PEG950 treatment.

2024-10-16 | GSE278503 | GEO

RNA-seq time course analysis of in vitro differentiated antibody-secreting cells

Project description:RNA-seq time course analysis of in vitro differentiated antibody-secreting cells

| PRJNA787966 | ENA

ATAC-seq time course analysis of in vitro differentiated antibody-secreting cells

Project description:ATAC-seq time course analysis of in vitro differentiated antibody-secreting cells

| PRJNA797034 | ENA

CD248 knockdown in in vitro differentiated adipocytes exposed to hypoxia

Project description:CD248 knockdown in in vitro differentiated adipocytes exposed to hypoxia

| PRJNA544327 | ENA

Circadian time course

Project description:Circadian time course

| PRJNA98585 | ENA

Time-course transcriptome analysis of in vitro differentiated Th17 cells from wild-type C57BL/6 mice

Project description:Time-course transcriptome analysis of in vitro differentiated Th17 cells from wild-type C57BL/6 mice

| PRJNA646394 | ENA

Expression data from hepatocyte-like cells (HLCs) differentiated from human induced pluripotent stem cells (iPSCs)

Project description:We devised two hepatocyte differentiation methods, namely Method 1 (M1) and Method 2 (M2), through modifying existing well-known hepatocyte differentiation strategies, and compared the resultant cells phenotypically, functionally and transcriptomically at different stages of hepatocyte differentiation. !Series_summary =We used microarrays to compare the global gene expression of the HLCs differentiated using the two methods, M1 and M2.

2021-11-03 | GSE187011 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data