Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptomic data in the spinal cord of Taiwanese type I SMA mice

ABSTRACT: transcriptomic data in the spinal cord of Taiwanese type I SMA mice

PROVIDER: PRJNA862954 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

transcriptomic data in the spinal cord of Taiwanese type I SMA mice

Project description:SMA is a neurodegenerative disease of unknown pathogenesis characterized by degeneration of motor neurons in the anterior horn of the spinal cord. Here we performed transcriptome sequencing of the spinal cord of a severe SMA mouse model.

2022-08-03 | GSE209926 | GEO

Single-cell transcriptomic data in the spinal cord of Taiwanese type I SMA mice

Project description:Although spinal muscular atrophy (SMA) is a motor neuron disease caused by the loss of survival of motor neuron protein, there is growing evidence that non-neuronal cells play important roles in SMA pathogenesis. However, transcriptome alterations occurring at the single-cell level in SMA spinal cord remain unknown, preventing us from fully comprehending the role of specific cells. Here, we performed single-cell RNA sequencing of the spinal cord of a severe SMA mouse model, and identified ten cell types as well as their differentially expressed genes.

2022-07-23 | GSE208629 | GEO

Single-cell transcriptomic data in the spinal cord of Taiwanese type I SMA mice

Project description:Single-cell transcriptomic data in the spinal cord of Taiwanese type I SMA mice

| PRJNA860370 | ENA

Gene Expression Analysis of spinal cord obtained from a mouse model of severe Spinal Muscular Atrophy (SMA)

Project description:Spinal Muscular Atrophy (SMA) is an autosomal recessive motor neuron disease and is the second most common genetic disorder leading to death in childhood. No effective therapy is currently available. It has been suggested that M-NM-2-lactam antibiotics such as ceftriaxone may offer neuroprotection in motoneuron disease. We investigated the therapeutic effect of ceftriaxone in a murine model of SMA. Microarray technology was used to assess the global gene expression profile of spinal cord obtained by ceftriaxone-treated and vehicle treated SMA mice. Comparative Gene Expression Analysis. The microarray data derived from three different groups: wildtype controls, transgenic SMA (vehicle treated) and ceftriaxone-treated SMA mice. Each population consists of four RNA profiling samples.

2013-12-01 | E-GEOD-19674 | biostudies-arrayexpress

Gene Expression Analysis of spinal cord obtained from a mouse model of severe Spinal Muscular Atrophy (SMA)

Project description:Spinal Muscular Atrophy (SMA) is an autosomal recessive motor neuron disease and is the second most common genetic disorder leading to death in childhood. No effective therapy is currently available. It has been suggested that β-lactam antibiotics such as ceftriaxone may offer neuroprotection in motoneuron disease. We investigated the therapeutic effect of ceftriaxone in a murine model of SMA. Microarray technology was used to assess the global gene expression profile of spinal cord obtained by ceftriaxone-treated and vehicle treated SMA mice.

2013-12-01 | GSE19674 | GEO

SMA cases and postnatal controls from spinal cord, diaphragm and iliopsoas tissues

Project description:The objective of the study was to compare gene expression across SMA cases and postnatal controls in spinal cord, diaphragm and iliopsoas tissues. This dataset was used in the testing of the GENDULF algorithm.

2020-10-23 | GSE159642 | GEO

RNA-seq of spinal cord, brain, liver, and muscle from an SMA mouse model

Project description:This study describes RNA-seq results from total spinal cord, brain, liver and muscle samples taken at PND1 and PND5 from an SMA mouse model paired with samples taken from heterozygous litter-mates. There are four mouse in each group.

2016-08-25 | E-MTAB-3664 | biostudies-arrayexpress

Gene Expression Analysis of laser-microdissected motorneurons in Spinal Muscular Atrophy (SMA)

Project description:Spinal Muscular Atrophy (SMA) is an autosomal recessive motor neuron disease and is the second most common genetic disorder leading to death in childhood. Stem cell transplantation could represent a therapeutic approach for motor neuron diseases such as SMA. We examined the theraputics effects of a spinal cord neural stem cell population and their ability to modify SMA phenotype. Microarray technology was used to assess the global gene expression profile of laser-microdissected motoneurons obtained by transplanted and veichle treated SMA, and wildtype mice. Keywords: Comparative Gene Expression Analysis

2008-08-06 | GSE10224 | GEO

Transcription profiling of mouse laser-microdissected motorneurons in a Spinal Muscular Atrophy model (SMA)

Project description:Spinal Muscular Atrophy (SMA) is an autosomal recessive motor neuron disease and is the second most common genetic disorder leading to death in childhood. Stem cell transplantation could represent a therapeutic approach for motor neuron diseases such as SMA. We examined the theraputics effects of a spinal cord neural stem cell population and their ability to modify SMA phenotype. Microarray technology was used to assess the global gene expression profile of laser-microdissected motoneurons obtained by transplanted and veichle treated SMA, and wildtype mice. Experiment Overall Design: The microarray data derived from three different groups: wildtype controls (vehicle treated), transgenic SMA (vehicle treated) and transplanted SMA mice. Each population consists of three RNA profiling samples.

2008-10-20 | E-GEOD-10224 | biostudies-arrayexpress

SMA cases and postnatal controls from spinal cord, diaphragm and iliopsoas tissues

Project description:SMA cases and postnatal controls from spinal cord, diaphragm and iliopsoas tissues

| PRJNA669882 | ENA