Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Microglia care for neurons through tunneling nanotubes

ABSTRACT: Microglia care for neurons through tunneling nanotubes

PROVIDER: PRJNA863248 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR20693801.fastq.gz	Fastqsanger.gz
	SRR20693802.fastq.gz	Fastqsanger.gz
	SRR20693803.fastq.gz	Fastqsanger.gz
	SRR20693804.fastq.gz	Fastqsanger.gz
	SRR20693805.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 27

Similar Datasets

Microglia care for neurons through tunneling nanotubes [Dataset 2 Microglia mRNA-seq]

Project description:Microglia care for neurons through tunneling nanotubes [Dataset 2 Microglia mRNA-seq]

| PRJNA863253 | ENA

Microglia care for neurons through tunneling nanotubes [Dataset 1 Neurons mRNA-seq]

Project description:Microglia care for neurons through tunneling nanotubes [Dataset 1 Neurons mRNA-seq]

| PRJNA863252 | ENA

Microglia care for neurons through tunneling nanotubes [Dataset 2 Microglia mRNA-seq]

Project description:We report the transfer of alpha-s-ynuclein aggregates from neurons to microglia and examined transcriptomic changes following protein extraction. By obtaining RNA samples, we performed differential expression analysis and generated gene ontology enrichment and network analysis.

2023-12-01 | GSE209971 | GEO

Microglia care for neurons through tunneling nanotubes [Dataset 1 Neurons mRNA-seq]

2023-12-01 | GSE209970 | GEO

Microglia care for neurons through tunneling nanotubes

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-12-01 | GSE209972 | GEO

CO-culture of Microglia and Neurons

Project description:CO-culture of Microglia and Neurons. The NC/ APOE knocked down/ CD74 knocked down BV2 was stimulated by the ACP cystic fluid for 48 hours.

2024-11-21 | PXD058159 |

Single-cell RNA-seq of rat microglia in monoculture and in coculture with neurons and astrocytes

Project description:Microglia, brain resident macrophages, require instruction from the central nervous system microenvironment to maintain their identity, morphology, and to regulate inflammatory responses. We investigated the heterogeneity of response of microglia to the presence of neurons and astrocytes by performing single-cell sequencing of microglia in both monoculture, and in coculture with neurons and astrocytes.

2021-03-23 | E-MTAB-10030 | biostudies-arrayexpress

Transcriptional response to flavivirus infection in neurons, astrocytes and microglia in vivo and in vitro

Project description:Bulk RNA-seq comparison of neurons, astrocytes and microglia, after infection with LGTV, TBEV and control.

2023-10-27 | E-MTAB-12902 | biostudies-arrayexpress

Neurons burdened by DNA double strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration.

Project description:DNA double strand breaks (DSBs) are linked to neurodegeneration and senescence. However, it is not clear how DSB-bearing neurons influence neuroinflammation associated with neurodegeneration. Here, we characterize DSB-bearing neurons from the CK-p25 mouse model of neurodegeneration using single-nucleus, bulk, and spatial transcriptomic techniques. DSB-bearing neurons enter a late-stage DNA damage response marked by NFκB-activated senescent and antiviral immune pathways. In humans, Alzheimer’s disease pathology is significantly associated with immune activation in excitatory neurons. Spatial transcriptomics reveal that regions of CK-p25 brain tissue dense with DSB-bearing neurons harbor signatures of inflammatory microglia, which is ameliorated by NFκB knock-down in neurons. Inhibition of NFκB in DSB-bearing neurons also reduces microglia activation in organotypic mouse brain slice culture. In conclusion, DSBs activate immune pathways in neurons, which in turn adopt a senescence-associated secretory phenotype to elicit microglia activation. These findings highlight a novel role for neurons in the mechanism of disease-associated neuroinflammation.

2022-05-10 | GSE174265 | GEO

A novel FACS-based method to isolate enriched populations of neurons, astrocytes, and microglia

Project description:We developed a novel FACS-based method to isolate enriched populations of neurons, astrocytes, and microglia. Whole mouse brains were digested, and populations of neurons, astrocytes, and microglia were subsequently enriched by FACS using a combination of positive gating on cell-type specific markers and stringent negative selection against markers of oligodendrocytes and endothelial cells. We confirmed a strong enrichment of corresponding cell-type specific genes in isolated populations and a reduction in gene markers of endothelial cells and oligodendrocytes, demonstrating that highly pure populations of neurons, astrocytes, and microglia were obtained.

2020-09-16 | GSE139000 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data