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Microglia care for neurons through tunneling nanotubes [Dataset 2 Microglia mRNA-seq]

ABSTRACT: Microglia care for neurons through tunneling nanotubes [Dataset 2 Microglia mRNA-seq]

PROVIDER: PRJNA863253 | ENA |

REPOSITORIES: ENA

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Microglia care for neurons through tunneling nanotubes

Project description:Microglia care for neurons through tunneling nanotubes

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Microglia care for neurons through tunneling nanotubes [Dataset 1 Neurons mRNA-seq]

Project description:Microglia care for neurons through tunneling nanotubes [Dataset 1 Neurons mRNA-seq]

| PRJNA863252 | ENA

Microglia care for neurons through tunneling nanotubes [Dataset 2 Microglia mRNA-seq]

Project description:We report the transfer of alpha-s-ynuclein aggregates from neurons to microglia and examined transcriptomic changes following protein extraction. By obtaining RNA samples, we performed differential expression analysis and generated gene ontology enrichment and network analysis.

2023-12-01 | GSE209971 | GEO

Microglia care for neurons through tunneling nanotubes [Dataset 1 Neurons mRNA-seq]

2023-12-01 | GSE209970 | GEO

Microglia care for neurons through tunneling nanotubes

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-12-01 | GSE209972 | GEO

RNA-seq of rat microglia, mouse neurons and human astrocytes in co-culture, challenged with different concentrations of LPS - dataset 2

Project description:We investigated non-cell-autonomous regulation of gene expression in microglia by neurons and astrocytes, by co-culturing these cell types (derived from different mammalian species) together, and then separating the RNA-seq reads from each cell type/species in silico. This submission forms a companion to the data in E-MTAB-5987. We investigated non-cell-autonomously regulated gene expression in microglia by co-culturing these cell types (derived from different mammalian species) together, and then separating the RNA-seq reads from each cell type/species in silico.

2021-03-23 | E-MTAB-7776 | biostudies-arrayexpress

Microarray dataset of gene transcription in mouse microglia and peripheral monocytes in contextual fear conditioning

Project description:Using Illumina MouseWG-6v2 microarrays, we investigated the gene transcription changes in microglia and peripheral monocytes after contextual fear conditioning of C57BL/6J mice. Mice were trained with or without a single minimized footshock stimulation (0-s or 2-s, 0.4 mA) and re-exposed to the training context without footshock for three different durations 24 h later: 0 min (FS0), 3 min (FS3), or 30 min (FS30). Whole brain microglia and peripheral monocytes were prepared 24 h after re-exposure using a neural tissue dissociation kit, including non-footshock controls for two re-exposure durations (Con3 and Con30). The data can be valuable for researchers interested in glial cells and neurotransmission studies and are related to the research article “Contextual fear conditioning regulates synapse-related gene transcription in mouse microglia”.

2022-10-28 | E-MTAB-12361 | biostudies-arrayexpress

Single-cell RNA-seq of rat microglia in monoculture and in coculture with neurons and astrocytes

Project description:Microglia, brain resident macrophages, require instruction from the central nervous system microenvironment to maintain their identity, morphology, and to regulate inflammatory responses. We investigated the heterogeneity of response of microglia to the presence of neurons and astrocytes by performing single-cell sequencing of microglia in both monoculture, and in coculture with neurons and astrocytes.

2021-03-23 | E-MTAB-10030 | biostudies-arrayexpress

Tunneling nanotubes contribute to the stroma-mediated imatinib resistance of leukemic cells

Project description:Intercellular communication within the bone marrow niche significantly influences leukemogenesis and the sensitivity of leukemic cells to therapy. However, the landscape of possible cell-cell interactions is still incomplete. Tunneling nanotubes (TNTs) are a novel mode of intercellular cross-talk. They are long, thin membranous conduits that enable the direct transfer of various cargo between cells. The present study found that TNTs are formed between leukemic and bone marrow stromal cells. Confocal three-dimensional reconstructions, correlative light-electron microscopy, and electron tomography provided evidence that TNTs transfer cellular vesicles between cells. The quantitative analysis demonstrated the stimulation of TNT-mediated vesicle transfer from stromal cells to leukemic cells by the stromal component. The vesicular cargo that was received from stroma cells conferred resistance to anti-leukemic treatment. Moreover, specific sets of proteins with a potential role in survival and the drug response were transferred within these vesicles. Altogether, we found that TNTs are involved in a novel and potent mechanism that participates in leukemia-stroma cross-talk and the stroma-mediated cytoprotection of leukemic cells. Our findings implicate TNT connections as a possible target for therapeutic interventions within the leukemia microenvironment to attenuate stroma-conferred protection.

2022-02-16 | PXD011013 | Pride

Tunneling nanotubes contribute to the stroma-mediated imatinib resistance of leukemic cells DID

2019-11-11 | PXD013504 | Pride