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Expression profile of ATF2 knockdown in gastric cancer cell line MGC803 and genome-wide maps of ATF2 binding sites in gastric cancer cell line AGS [RNA-Seq]

ABSTRACT: Expression profile of ATF2 knockdown in gastric cancer cell line MGC803 and genome-wide maps of ATF2 binding sites in gastric cancer cell line AGS [RNA-Seq]

PROVIDER: PRJNA876740 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21420290_1.fastq.gz	Fastqsanger.gz
	SRR21420290_2.fastq.gz	Fastqsanger.gz
	SRR21420291_1.fastq.gz	Fastqsanger.gz
	SRR21420291_2.fastq.gz	Fastqsanger.gz
	SRR21420292_1.fastq.gz	Fastqsanger.gz

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Expression profile of ATF2 knockdown in gastric cancer cell line MGC803 and genome-wide maps of ATF2 binding sites in gastric cancer cell line AGS

Project description:Expression profile of ATF2 knockdown in gastric cancer cell line MGC803 and genome-wide maps of ATF2 binding sites in gastric cancer cell line AGS

| PRJNA876738 | ENA

Expression profile of ATF2 knockdown in gastric cancer cell line MGC803 and genome-wide maps of ATF2 binding sites in gastric cancer cell line AGS [ChIP-Seq]

Project description:Expression profile of ATF2 knockdown in gastric cancer cell line MGC803 and genome-wide maps of ATF2 binding sites in gastric cancer cell line AGS [ChIP-Seq]

| PRJNA876741 | ENA

mRNA profiling of AGS gastric cancer cell line upon CTNNB1 silencing

Project description:Beta-catenin (CTNNB1) is a major component of Wnt signaling pathway and a crucial player in gastric cancer. To delineate the complex transcription program governed by CTNNB1 in gastric cancer cells, CTNNB1 was silenced in AGS, a commonly used Wnt signaling activated gastric cancer cell line and the resultant changes in genome-wide mRNA expression pattern was profiled using Affymetrix Human Gene 1.0 ST Array.

2015-12-01 | GSE61687 | GEO

Expression profile of ATF2 knockdown in gastric cancer cell line MGC803 and genome-wide maps of ATF2 binding sites in gastric cancer cell line AGS [ChIP-Seq]

Project description:Activation transcription factor 2 (ATF2), a member of the ATF/CREB family of transcription factors, is implicated in a broad spectrum of cancer-related biological functions, such as cell proliferation, apoptosis and DNA repair. Growing evidence indicates ATF2 act as an oncogene or a tumor suppressor in different cancer types depending on its expression level and subcellular localization. In this study, RNA-seq and ChIP-seq were performed for identification of genome-wide DNA binding sites and potential transcription targets for ATF2.

2024-09-01 | GSE212685 | GEO

Expression profile of ATF2 knockdown in gastric cancer cell line MGC803 and genome-wide maps of ATF2 binding sites in gastric cancer cell line AGS [RNA-Seq]

2024-09-01 | GSE212684 | GEO

Expression data of EBV-positive and EBV-negative subclones of gastric adenocarcinoma cell line AGS

Project description:Gastric cancer is one of the most common cancers worldwide. Epstein-Barr virus-associated gastric cancer accounts for approximately 10% of all gastric cancers. EBV expresses its own proteins and miRNAs (BART miRNAs) and regulates host gene expression. In this study, we examined the effect of EBV infection on host mRNA expression. Differential gene expression was analyzed between EBV-negative human gastric cancer cell line AGS and EBV-positive human gastric cancer cell line AGS-EBV.

2019-10-14 | GSE135644 | GEO

mRNA profiling in gastric cancer cell line AGS upon miR-25-3p silencing

Project description:Genome-wide mRNA expression profiling was performed in AGS, gastric cancer cell line, upon miR-25 silencing. At 48 hours upon anti-miR-25-3p (miRNA inhibitor) and non-targeting control RNA transfection, the whole transcriptome profiling was performed in triplicates. The miR-25 silencing elevates the diffuse gastric cancer features like expression of COL1A2, expression of COL1A2 co-expressed genes, Epithelial to Mesenchymal Transition (EMT) and angiogenesis associated genes.

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mRNA profiling of AGS Gastric Cancer cell line treated with the Homeopathy formulation, Ornithogalum

Project description:Ornithogalum is one of the therapeutic formulation used in homeopathic treatments. It is specifically used in the treatment for gastric and duodenal ulcerations. Towards understanding the anticancer mechanism, we investigated the genome-wide mRNA changes upon treating AGS Gastric Cancer cells with Ornithogalum. We observed that totally 707 genes were significantly regulated upon Ornithogalum Treatment, among them 246 genes were upregulated and 461 genes were downregulated. The results provide insight into molecular implication and gene level expression of AGS upon treatment with Ornithogalum. Total RNA was isolated from AGS gastric cancer cells treated with 0.01% of ornithogalum and ethanol control and profiled using Affymetrix Human Gene 1.0 ST Array (HuGene-1_0-st).

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mRNA profiling of AGS Gastric Cancer cell line upon treatment with 5µM of Doxycycline

Project description:Doxycycline, a tetracycline based antibiotic which has bacteriostatic activity against a broad range of both gram positive and gram negative bacteria was identified to inhibit the expression of ERK/MAPK signaling pathway in gastric cancer. ERK/MAPK pathway is one of the highly activated and a crucial player in gastric cancer progression. To delineate the complex transcription program associated with ERK/MAPK pathway and thus inhibited by doxycycline in gastric cancer cells, doxycycline was treated in AGS, one of the ERK/MAPK overexpressed gastric cancer cell line. The resulatant changes in genome-wide mRNA expression pattern between control and doxycycline treated was profiled using Human Transcriptome 2.0 arrays.

2021-01-06 | GSE124022 | GEO