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The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function

ABSTRACT: The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function

PROVIDER: PRJNA877113 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21434163_1.fastq.gz	Fastqsanger.gz
	SRR21434163_2.fastq.gz	Fastqsanger.gz
	SRR21434164_1.fastq.gz	Fastqsanger.gz
	SRR21434164_2.fastq.gz	Fastqsanger.gz
	SRR21434165_1.fastq.gz	Fastqsanger.gz

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The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function

Project description:2-hydroxyglutarate (2HG) is a by-product of the TCA cycle, and is readily detected in the tissues of healthy individuals. 2HG is found in two enantiomeric forms: S-2HG and R-2HG. Here, we investigate the differential roles of these two enantiomers in CD8+ T cell biology, where we found they had highly divergent effects on proliferation, differentiation, and T cell function. We show here an analysis of structural determinants that likely underlie these differential effects on specific a-ketoglutarate (aKG)-dependent enzymes. Treatment of CD8+ T cells with exogenous S-2HG, but not R-2HG, increased CD8+ T cell fitness in vivo, and enhanced anti-tumour activity. These data show that S-2HG and R-2HG should be considered as two distinct and important actors in the regulation of T cell function.

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