Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mutations in cdon and boc affect trunk neural crest cell migration and slow-twitch muscle development in zebrafish

ABSTRACT: Mutations in cdon and boc affect trunk neural crest cell migration and slow-twitch muscle development in zebrafish

PROVIDER: PRJNA882122 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR21631156_1.fastq.gz	Fastqsanger.gz
	SRR21631156_2.fastq.gz	Fastqsanger.gz
	SRR21631157_1.fastq.gz	Fastqsanger.gz
	SRR21631157_2.fastq.gz	Fastqsanger.gz
	SRR21631158_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Mutations in cdon and boc affect trunk neural crest cell migration and slow-twitch muscle development in zebrafish

Project description:Bulk RNA-seq of isolated slow-twtich muscle and neural crest cells from 24 hours post fertilization zebrafish.

2023-07-03 | GSE213728 | GEO

Molecular events controlling cessation of trunk neural crest migration and onset of differentiation

Project description:Neural crest cells migrate extensively in vertebrate embryos to populate diverse derivatives including ganglia of the peripheral nervous system. Little is known about the molecular mechanisms that tell migrating trunk neural crest cells to settle at selected sites in the embryo by ceasing migration and initiating differentiation programs.

2019-11-02 | GSE139859 | GEO

Trunk neural crest gene MOXD1 affects embryonic development

Project description:Ectoderm-derived neural crest is a transient structure arising during early embryogenesis in vertebrates. Neural crest consists of four derivatives based on their anterior- to posterior location along the body axis; cranial, vagal, trunk and sacral, respectively. We recently showed that trunk neural crest-specific gene MOXD1 functions as a tumor suppressor in trunk neural crest-derived childhood cancer form neuroblastoma and is essential for proper development of healthy adrenal glands. However, the role of MOXD1 during early embryogenesis is not known. Here, we conditionally knocked out MOXD1 in trunk neural crest cells before they become lineage-committed, using a CRISPR/Cas9 approach in chick embryos. Assessment of embryo growth showed that knockout of MOXD1 delayed development with knockout embryos being smaller. RNA sequencing of trunk-derived neural crest cells from control and knockout embryos showed enrichment of genes connected to gland development, copper ion metabolism and neuroblastoma progression. In conclusion, MOXD1 is important during early and prolonged embryonic development with effects on gland formation, possibly mediated via its role in copper metabolism.

2023-09-13 | GSE242700 | GEO

Cancer associated HIF-2a governs trunk neural crest stemness

Project description:We report that cancer associated protein HIF-2a is expressed in trunk neural crest neuroblastoma precursor cells in the developing embryo in three different species; human, mouse and avian. Dysregulation of HIF-2a leads to alterations in embryonic development, and neural crest cell migration, proliferation and self-renewal capacity. With RNAsequencing we report that alterations of HIF-2a expression affects the global transcriptome and that gene ontology enrich for the same processes observed in vivo.

2021-02-24 | GSE140319 | GEO

Molecular events controlling cessation of trunk neural crest migration and onset of differentiation

Project description:Molecular events controlling cessation of trunk neural crest migration and onset of differentiation

| PRJNA587159 | ENA

Trunk neural crest gene MOXD1 affects embryonic development

Project description:Trunk neural crest gene MOXD1 affects embryonic development

| PRJNA1014377 | ENA

Axial progenitors generate trunk neural crest cells in vitro

Project description:The in vitro generation of neural crest (NC) cells from human pluripotent stem cells (hPSCs) is a valuable approach to study human NC biology and isolate NC derivatives for disease modelling/regenerative medicine applications. However, conventional differentiation protocols induce only a modest yield of NC cells corresponding to the trunk level. Here we show that trunk NC cells and, their downstream derivatives, sympathoadrenal progenitors, can be produced at a high efficiency from hPSC-derived axial progenitors, the in vitro counterparts of the posteriorly-located drivers of embryonic axis elongation. Moreover, using transcriptome analysis, we define the molecular signatures associated with the emergence of human NC cells of distinct axial identities. Collectively, our findings indicate that a post-cranial NC state is achieved through two different routes: the birth of cardiac and vagal NC is facilitated by retinoic acid-induced posteriorisation of an anterior precursor whereas a trunk fate relies on a posterior axial progenitor intermediate.

2018-08-10 | GSE109267 | GEO

Axial progenitors generate trunk neural crest cells in vitro

Project description:Axial progenitors generate trunk neural crest cells in vitro

| PRJNA430261 | ENA

Cancer associated HIF-2a governs trunk neural crest stemness

Project description:Cancer associated HIF-2a governs trunk neural crest stemness

| PRJNA589281 | ENA

Ancient vertebrate dermal armor evolved from trunk neural crest

Project description:Ancient vertebrate dermal armor evolved from trunk neural crest

| PRJNA985650 | ENA