Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

T-cell responses to a specific antigen

ABSTRACT: T-cell responses to a specific antigen

PROVIDER: PRJNA884312 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR21709447_1.fastq.gz	Fastqsanger.gz
	SRR21709447_2.fastq.gz	Fastqsanger.gz
	SRR21709448_1.fastq.gz	Fastqsanger.gz
	SRR21709448_2.fastq.gz	Fastqsanger.gz
	SRR21709449_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

Brugia malayi filarial helminth-derived extracellular vesicles suppress antigen presenting cell functions and antigen-specific CD4+ T cell responses

Project description:Brugia malayi filarial helminth-derived extracellular vesicles suppress antigen presenting cell functions and antigen-specific CD4+ T cell responses

| PRJNA1098733 | ENA

Molecular Analysis of antigen-specific B cell responses

Project description:In order to better understand the factors that regulate B cell differentiation upon exposure to antigen, we compares global gene expression profiles from naive B cells with antigen-specific plasma, germinal center, and memory B cells after immunization with the T-dependent antigen, NP-CGG. The memory B cell-enriched transcripts were then compared with memory T cell-enriched and hematopoietic stem cell-enriched transcripts in order to generate a transcriptional profile of self-renewal within the hematopoietic system. Keywords: Cell Type Comparison

2006-02-02 | GSE4142 | GEO

Nanoparticle immunoadjuvant complexes augment antigen-specific germinal center responses and enhance humoral immunity

Project description:An alluring strategy for improving protective humoral immunity against infectious diseases would be to directly target the germinal center (GC). There remains a critical need for next generation vaccine approaches to elicit more potent GC responses and durable humoral immunity. Here, we investigated whether cytokines could be scaffolded on nanoparticles to further enhance antigen-specific GC responses. We designed a chimeric nanoparticle using the GT8-60mer, a germline-targeting HIV immunogen, as a model to scaffold IL-21. Nanoparticle immunoadjuvant complexes (NICs) scaffolding GT8 and IL-21 (GT8-IL-21-NIC) drove improved serum antibody titers, antigen-specific GC B cells, and functional Tfh cell responses relative to antigen-only nanoparticles and to co-delivery of IL-21 monomer. Single-cell RNA sequencing of antigen-specific GC B cells from GT8-IL-21-NIC immunized mice demonstrated upregulation of LZ and selection-associated gene signatures. The NIC platform was versatile and could support changes to both the antigen and cytokine domains utilizing numerous GC-associated cytokines. Thus, NICs may provide value as a tool to improve antigen-specific vaccine-induced immunity.

2025-10-01 | GSE278580 | GEO

Transcriptional responses of T cells activated via CD22-specific T cell receptor compared to CD22-specific chimeric antigen receptor

Project description:Transcriptional responses of T cells activated via CD22-specific T cell receptor compared to CD22-specific chimeric antigen receptor

| PRJNA1074674 | ENA

Antigen-level resolution of commensal-specific B cell responses enabled by phage-display screening and B cell tetramers

Project description:Antigen-level resolution of commensal-specific B cell responses enabled by phage-display screening and B cell tetramers

| PRJNA1026914 | ENA

A discrete subset of epigenetically primed human NK cells mediates antigen-specific immune responses

Project description:Adaptive features of natural killer (NK) cells have been reported in various species with different underlying mechanisms. It is unclear, however, which NK cell populations are capable of mounting antigen-specific recall responses, and how such functions are regulated at the molecular level. Here we identify and characterize a discrete population of CD49a+CD16- NK cells in the human liver that display increased epigenetic potential to elicit memory responses and has the functional properties to exert antigen-specific immunity on the skin as an effector site. Integrated chromatin-based epigenetic and transcriptomic profiling revealed unique characteristics of hepatic CD49a+CD16- NK cells when compared to conventional CD49a-CD16+ NK cells thereby defining active genomic regions and molecules underpinning distinct NK cell reactivity. In contrast to conventional NK cells, our results suggest adaptive CD49a+CD16- NK cells to be able to bypass the KIR receptor-ligand system upon antigen-specific stimulation. Furthermore, these cells were highly migratory towards chemokine gradients expressed in epicutaneous patch test lesions as an effector site of adaptive immune responses of the skin. These results define pathways operative in human antigen-specific memory NK cells and provide a roadmap for harnessing this NK cell subset for specific therapeutic or prophylactic vaccine strategies.

2020-10-15 | GSE158485 | GEO

Single cell analysis of diverse pathogen responses defines a molecular roadmap for generating antigen-specific immunity

Project description:Single cell analysis of diverse pathogen responses defines a molecular roadmap for generating antigen-specific immunity

| PRJNA515047 | ENA

Antigen-specific T-cell receptor signatures of cytomegalovirus infection

Project description:Antigen-specific T-cell receptor signatures of cytomegalovirus infection

| PRJNA473147 | ENA

Transcriptional responses of antigen-specific CD8 T cells after secondary influenza virus challenge

Project description:Transcriptional responses of antigen-specific CD8 T cells after secondary influenza virus challenge

| PRJNA1038717 | ENA

Nanoparticle immunoadjuvant complexes augment antigen-specific germinal center responses and enhance humoral immunity

Project description:Nanoparticle immunoadjuvant complexes augment antigen-specific germinal center responses and enhance humoral immunity