Molecular mechanisms of coronary artery disease risk at the PDGFD locus
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ABSTRACT:
PROVIDER: PRJNA885311 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR21751500.fastq.gz | Fastqsanger.gz | |||
| SRR21751501.fastq.gz | Fastqsanger.gz | |||
| SRR21751502.fastq.gz | Fastqsanger.gz | |||
| SRR21751503.fastq.gz | Fastqsanger.gz | |||
| SRR21751504.fastq.gz | Fastqsanger.gz |
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Project description:The 9p21.3 genetic locus is a well-established risk factor for coronary artery disease (CAD), however there is much about its exact mechanism that is yet to be established. To explore the impact of the 9p21.3 CAD risk locus on gene expression within a pathologically relevant cell type the transcriptome profiles of 9p21.3 homozygous risk (HR), heterozygous (HET) and homozygous non-risk (HNR) genotypes were determined in primary human aortic smooth muscle cells (HAoSMC). Total RNA was isolated from 4 HR, 4 HET and 3 HNR primary cells and gene expression quantified using the Affymetrix Human Gene 1.0 ST array.
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