VMP1 restricts NLRP3 inflammasome activation through its modulation of SERCA activity and autophagy
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA890259 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR21892084_1.fastq.gz | Fastqsanger.gz | |||
| SRR21892084_2.fastq.gz | Fastqsanger.gz | |||
| SRR21892085_1.fastq.gz | Fastqsanger.gz | |||
| SRR21892085_2.fastq.gz | Fastqsanger.gz | |||
| SRR21892086_1.fastq.gz | Fastqsanger.gz |
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Project description:This experiment was performed to analyze the contribution of NLRP3 inflammasome activation to age-related changes in hippocampal RNA. The hypothesis was that decreased inflammasome activation would reduce hippocampal inflammation. Results indicate that inflammasome knockout animals are protected from age-related changes in hippocampal gene expression Gene expression profiles of young (1 month) and old (21-23 month) wild type, CIAS -/- and ASC -/- mouse hippocampal tissue were compared. Total mRNA was extracted using Trizol.
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Project description:Inhibition of NLRP3 Inflammasome Activation by A20 through Modulation of NEK7
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