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Engineered T cell therapy for central nervous system injury [FACS-Tcells]

ABSTRACT: Engineered T cell therapy for central nervous system injury [FACS-Tcells]

PROVIDER: PRJNA893393 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22017700.fastq.gz	Fastqsanger.gz
	SRR22017800.fastq.gz	Fastqsanger.gz
	SRR22017900.fastq.gz	Fastqsanger.gz
	SRR22017701.fastq.gz	Fastqsanger.gz
	SRR22017801.fastq.gz	Fastqsanger.gz

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Engineered T cell therapy for central nervous system injury [FACS-Tcells]

Project description:Traumatic injuries to the central nervous system (CNS) affect millions of people worldwide yet lack an effective treatment. These injuries contain infiltrating immune cells that can promote tissue repair and could be exploited for therapeutic benefit. Here, using single-cell RNA-sequencing of T cells infiltrating the injured CNS we demonstrate their clonal expansion and antigen specificity towards CNS derived self-peptides. We confirm the beneficial effect of these injury-associated autoimmune CD4+ T cells in murine models of optic nerve and spinal cord injury. Subsequently, using mRNA-based transient T cell receptor (TCR) reconstitution, we demonstrate a therapeutic T cell strategy to alleviate CNS injury. Treatment of CNS-injured mice with this therapy improved locomotion and alleviated histological signs of damage, through regulation of myeloid cells, without detrimental autoimmune side effects. This strategy provides a means of developing custom-designed T cell therapies for CNS injury, and possibly for other neurodegenerative disorders.

2024-07-23 | GSE216388 | GEO

Engineered T cell therapy for central nervous system injury

Project description:Engineered T cell therapy for central nervous system injury

| PRJNA893390 | ENA

Engineered T cell therapy for central nervous system injury [CD45+ scRNA-seq]

Project description:Engineered T cell therapy for central nervous system injury [CD45+ scRNA-seq]

| PRJNA893395 | ENA

Engineered T cell therapy for central nervous system injury [CSF RNAseq + VDJ]

Project description:Engineered T cell therapy for central nervous system injury [CSF RNAseq + VDJ]

| PRJNA1142026 | ENA

Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer

Project description:RATIONALE: Radiolabeled monoclonal antibodies, such as iodine I 131 monoclonal antibody 3F8, can find tumor cells and carry tumor-killing substances to them without harming normal cells. This may be an effective treatment for central nervous system cancer or leptomeningeal metastases. PURPOSE: This phase II trial is studying the side effects and how well iodine I 131 monoclonal antibody 3F8 works in treating patients with central nervous system cancer or leptomeningeal cancer.

| 2037925 | ecrin-mdr-crc

Engineered T cell therapy for central nervous system injury [spinal cord TCR scRNA-seq]

Project description:Engineered T cell therapy for central nervous system injury [spinal cord TCR scRNA-seq]

| PRJNA893396 | ENA

Engineered T cell therapy for central nervous system injury [control tissues TCR scRNA-seq]

Project description:Engineered T cell therapy for central nervous system injury [control tissues TCR scRNA-seq]

| PRJNA784580 | ENA

Efavirenz Central Nervous System Side Effects

Project description:Efavirenz Central Nervous System Side Effects

| PRJNA354669 | ENA

Central nervous system-associated macrophages modulate the immune response following stroke in aged mice

Project description:To study the differential role of central nervous system-associated macrophages (CAMs) in neuroinflammation after stroke between young and aged mice, we FACS sorted CD3-CD11b+CD45+CD206+ CAMs from brains of C57BL/6 mice aged 2 months (young) and 18 months (old)

2024-05-22 | GSE267623 | GEO

Expression data from Human CD40L+ Tcells

Project description:To assess the nature of CD8+CD40L+ memory Tcells, we compared the gene expression to CD8+CD40L- and CD4+ counterparts, and found similarities in expression of genes encoding cytokines PBMCs were isolated from five healthy donors. The cells were stimulated with PMA/Ionomycin for 6 h, and subsequently sorted into the CD4+CD45RA-CD40L+, CD8+CD45RA-CD40L-, CD8+CD45RA-CD40L+ populations by FACS-sort

2013-08-05 | E-GEOD-44126 | biostudies-arrayexpress

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