Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Engineered T cell therapy for central nervous system injury [spinal cord TCR scRNA-seq]

ABSTRACT: Engineered T cell therapy for central nervous system injury [spinal cord TCR scRNA-seq]

PROVIDER: PRJNA893396 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR22018000_1.fastq.gz	Fastqsanger.gz
	SRR22018000_2.fastq.gz	Fastqsanger.gz
	SRR22018001_1.fastq.gz	Fastqsanger.gz
	SRR22018001_2.fastq.gz	Fastqsanger.gz
	SRR22018002_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

Engineered T cell therapy for central nervous system injury [spinal cord TCR scRNA-seq]

Project description:Traumatic injuries to the central nervous system (CNS) affect millions of people worldwide yet lack an effective treatment. These injuries contain infiltrating immune cells that can promote tissue repair and could be exploited for therapeutic benefit. Here, using single-cell RNA-sequencing of T cells infiltrating the injured CNS we demonstrate their clonal expansion and antigen specificity towards CNS derived self-peptides. We confirm the beneficial effect of these injury-associated autoimmune CD4+ T cells in murine models of optic nerve and spinal cord injury. Subsequently, using mRNA-based transient T cell receptor (TCR) reconstitution, we demonstrate a therapeutic T cell strategy to alleviate CNS injury. Treatment of CNS-injured mice with this therapy improved locomotion and alleviated histological signs of damage, through regulation of myeloid cells, without detrimental autoimmune side effects. This strategy provides a means of developing custom-designed T cell therapies for CNS injury, and possibly for other neurodegenerative disorders.

2024-07-23 | GSE216390 | GEO

Engineered T cell therapy for central nervous system injury [control tissues TCR scRNA-seq]

2024-07-23 | GSE189812 | GEO

Engineered T cell therapy for central nervous system injury [control tissues TCR scRNA-seq]

Project description:Engineered T cell therapy for central nervous system injury [control tissues TCR scRNA-seq]

| PRJNA784580 | ENA

Engineered T cell therapy for central nervous system injury

Project description:Engineered T cell therapy for central nervous system injury

| PRJNA893390 | ENA

Engineered T cell therapy for central nervous system injury [FACS-Tcells]

2024-07-23 | GSE216388 | GEO

Engineered T cell therapy for central nervous system injury [CD45+ scRNA-seq]