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Engineered T cell therapy for central nervous system injury [CD45+ scRNA-seq]

ABSTRACT: Engineered T cell therapy for central nervous system injury [CD45+ scRNA-seq]

PROVIDER: PRJNA893395 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22018009_1.fastq.gz	Fastqsanger.gz
	SRR22018009_2.fastq.gz	Fastqsanger.gz
	SRR22018010_1.fastq.gz	Fastqsanger.gz
	SRR22018010_2.fastq.gz	Fastqsanger.gz

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Engineered T cell therapy for central nervous system injury

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Engineered T cell therapy for central nervous system injury [CD45+ scRNA-seq]

Project description:Traumatic injuries to the central nervous system (CNS) affect millions of people worldwide yet lack an effective treatment. These injuries contain infiltrating immune cells that can promote tissue repair and could be exploited for therapeutic benefit. Here, using single-cell RNA-sequencing of T cells infiltrating the injured CNS we demonstrate their clonal expansion and antigen specificity towards CNS derived self-peptides. We confirm the beneficial effect of these injury-associated autoimmune CD4+ T cells in murine models of optic nerve and spinal cord injury. Subsequently, using mRNA-based transient T cell receptor (TCR) reconstitution, we demonstrate a therapeutic T cell strategy to alleviate CNS injury. Treatment of CNS-injured mice with this therapy improved locomotion and alleviated histological signs of damage, through regulation of myeloid cells, without detrimental autoimmune side effects. This strategy provides a means of developing custom-designed T cell therapies for CNS injury, and possibly for other neurodegenerative disorders.

2024-07-23 | GSE216389 | GEO

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Engineered T cell therapy for central nervous system injury [control tissues TCR scRNA-seq]

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Single cell analysis of CD45-positive immune cells infiltrating the central nervous system of mice undergoing experimental autoimmune encephalomyelitis.

Project description:C56BL/6 mice (10 to 12-week-old) were immunized subcutaneously at the base of the tail with 100 μg of MOG (35–55) emulsified in complete Freund's adjuvant containing 500 μg of Mycobacterium tuberculosis. Pertussis toxin (200 ng; List Biological Laboratories) was injected intravenously at days 0 and 2 post-immunization. At day 17 post immunization, central nervous system CD45-positive immune cells were isolated and loaded onto a single channel of a 10x Chromium chip for each sample.

2022-06-06 | E-MTAB-11294 | biostudies-arrayexpress

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Efavirenz Central Nervous System Side Effects

Project description:Efavirenz Central Nervous System Side Effects

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