Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Whole transcriptome analysis of neuroblastoma cell lines after ERK5 silencing

ABSTRACT: Whole transcriptome analysis of neuroblastoma cell lines after ERK5 silencing

PROVIDER: PRJNA895405 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Whole transcriptome analysis of neuroblastoma cell lines after ERK5 silencing

Project description:The transcriptomic network modulated after the depletion of the tyrosin kinase ERK5 through shRNA-mediated silencing was analyzed in SK-N-BE(2) and CHLA-90 neuroblastoma cell lines, in order to characterize and reveal any relevant role of this kinase at the transcriptional level.

2022-10-29 | GSE216790 | GEO

Whole transcriptome analysis of endometroid cell lines after ERK5 inhibition

Project description:Whole transcriptome analysis of endometroid cell lines after ERK5 inhibition

| PRJNA1001389 | ENA

Whole transcriptome analysis of endometroid cell lines after ERK5 inhibition

Project description:The transcriptomic network modulated after the inhibition of the nuclear tyrosin kinase ERK5 was analyzed Ishikawa endometroid cell line, in order to characterize and reveal any relevant role of this kinase at the transcriptional level.

2023-08-03 | GSE239920 | GEO

Neuroblastoma cell lines

Project description:Neuroblastoma cell lines

| PRJEB6889 | ENA

Neuroblastoma cell lines

Project description:Neuroblastoma cell lines

| PRJNA515054 | ENA

Neuroblastoma cell lines

Project description:WGS data of neuroblastoma classical cell lines

| PRJEB54725 | ENA

Neuroblastoma cell lines

Project description:RNA-Seq data of neuroblastoma classical cell lines

| PRJEB55331 | ENA

Gene expression profiling in neuroblastoma cells upon CHAF1A silencing

Project description:We used an inducible ShRNA system and microarrays to detail the global programme of gene expression underlying neuroblastoma differentiation upon CHAF1A silencing . CHAF1A is a subunit of the Chromatin Assembly Factor-1 (CAF1) and regulates H3K9-trimethylation. High expression of CHAF1A strongly correlates with neuroblastoma poor prognosis and loss-of-function drives neuronal differentiation in vitro and in vivo. Total RNA was isolated using RNAeasy kit from IMR32 cells transduced with inducible CHAF1A ShRNA. Gene expression profiling was performed in neuroblastoma cells upon CHAF1A silencing over time course (0, 5, and 10 days) in triplicate.

2013-11-01 | E-GEOD-51978 | biostudies-arrayexpress

Acute pharmacological degradation of ERK5 does not inhibit cellular immune response or proliferation

Project description:Over the past few decades, interest in the role that extracellular signal-regulated kinase 5 (ERK5) plays in various diseases, particularly cancer and inflammation, has grown. Phenotypes observed from genetic knockdown or deletion of ERK5 suggested that targeting ERK5 could have therapeutic potential in various disease settings, motivating the development of potent and selective ATP-competitive ERK5 inhibitors. However, these inhibitors were unable to recapitulate the effects of genetic loss of ERK5, suggesting that ERK5 may have key kinase-independent roles. To investigate potential non-catalytic functions associated with ERK5, we report here the development of INY-06-061, a potent and selective heterobifunctional degrader of ERK5. In contrast to results reported through genetic knockdown of ERK5, INY-06-061-induced ERK5 degradation did not induce anti-proliferative effects in multiple cancer cell lines or suppress inflammatory responses in primary endothelial cells. Thus, we have developed and characterized a chemical tool useful for validating phenotypes reported to be associated with genetic ERK5 ablation and for guiding future ERK5-directed drug discovery efforts.

2022-10-13 | PXD036105 | Pride

Acute pharmacological degradation of ERK5 does not inhibit cellular immune response or proliferation

2022-10-13 | PXD036104 | Pride