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MiRNA-seq of lungs tissue of swine supplemented with cholecalciferol and calcidiol

ABSTRACT: miRNA-seq of lungs tissue of swine supplemented with cholecalciferol and calcidiol

PROVIDER: PRJNA899803 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22244755.fastq.gz	Fastqsanger.gz
	SRR22244756.fastq.gz	Fastqsanger.gz
	SRR22244757.fastq.gz	Fastqsanger.gz
	SRR22244758.fastq.gz	Fastqsanger.gz
	SRR22244759.fastq.gz	Fastqsanger.gz

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miRNA-seq of lungs tissue of swine supplemented with cholecalciferol and calcidiol

Project description:Results indicate that both increasing the dose of cholcalciferol and the use of calcidiol in the diet have a significant effect on lung tissue miRNAs compared to using the standard dose of cholecalciferol. The greatest changes in the transcriptome were induced by supplementation with the increased dose of the combination of cholecalciferol and calcidiol.

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Project description:Maintaining an appropriate concentration of vitamin D is essential for the proper functioning of the body regardless of age. Nowadays, there are more and more indications that vitamin D supplementation at higher than standard doses may show protective and therapeutic effects. Our study identifies differences in the body's response to long-term supplementation of cholecalciferol at an increased dose. Two groups of pigs were used in the experiment. The first group received a standard dose of cholecalciferol (grower- 2000 and finisher- 1500 IU/kg feed), and the second group received an increased dose (grower- 3000 and finisher- 2500 IU/kg feed). The animals were slaughtered when they reached breeding maturity. Then the lung tissue was collected from the animals. The material was used for mRNA sequencing. The results of mRNA sequencing showed a significant change in the expression of 195 genes. Functional analysis using the KEGG database showed that increased cholecalciferol supplementation significantly activated 42 pathways. Most of the activated pathways is associated with metabolism.

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