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MiRNA-seq of lungs tissue of swine supplemented with cholecalciferol and calcidiol

ABSTRACT: miRNA-seq of lungs tissue of swine supplemented with cholecalciferol and calcidiol

PROVIDER: PRJNA899803 | ENA |

REPOSITORIES: ENA

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miRNA-seq of lungs tissue of swine supplemented with cholecalciferol and calcidiol

Project description:Results indicate that both increasing the dose of cholcalciferol and the use of calcidiol in the diet have a significant effect on lung tissue miRNAs compared to using the standard dose of cholecalciferol. The greatest changes in the transcriptome were induced by supplementation with the increased dose of the combination of cholecalciferol and calcidiol.

2023-11-23 | GSE217599 | GEO

NGS-Muscle of swine supplemented with cholecalciferol and 25(OH)D

Project description:NGS-Muscle of swine supplemented with cholecalciferol and 25(OH)D

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NGS-Muscle of swine supplemented with cholecalciferol and 25(OH)D

Project description:According to RNA-seq results, application of vitamin D in the form of 25(OH)D in swine diet can be beneficial for myogenesis, energy production and muscle fibre formation by influencing TOR signalling pathway. However, the use of vitamin D in the form of 25(OH)D may reduce muscle respiratory capacity.

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The Gene Expression Profile of Lung Tissue Following Sulfur Mustard Inhalation Exposure in Large Anesthetized Swine

Project description:Sulfur mustard (HD) is a vesicating agent that targets the eyes, skin, and lungs, producing skin burns, conjunctivitis, and compromised respiratory function. Underlying mechanisms of this damage are a critical area of research for the development of medical countermeasures. This study utilized mRNA analysis to evaluate molecular effects of HD on lung tissue from anesthetized swine inhalationally exposed to HD Anesthetized large swine were exposed for 10 minutes to either air, 60 ug/kg (low), or 100ug/kg (medium) HD vapor. At 12 hours, animals were euthanized, lungs removed and dissected by lobe, and stabilized in RNAlater. Total RNA was isolated and processed for hybridization to Affymetrix Porcine GeneChip.

2016-09-01 | E-GEOD-73088 | biostudies-arrayexpress

Changes in mRNA expression in lung tissue after long-term supplementation with an increased dose of cholecalciferol.

Project description:Maintaining an appropriate concentration of vitamin D is essential for the proper functioning of the body regardless of age. Nowadays, there are more and more indications that vitamin D supplementation at higher than standard doses may show protective and therapeutic effects. Our study identifies differences in the body's response to long-term supplementation of cholecalciferol at an increased dose. Two groups of pigs were used in the experiment. The first group received a standard dose of cholecalciferol (grower- 2000 and finisher- 1500 IU/kg feed), and the second group received an increased dose (grower- 3000 and finisher- 2500 IU/kg feed). The animals were slaughtered when they reached breeding maturity. Then the lung tissue was collected from the animals. The material was used for mRNA sequencing. The results of mRNA sequencing showed a significant change in the expression of 195 genes. Functional analysis using the KEGG database showed that increased cholecalciferol supplementation significantly activated 42 pathways. Most of the activated pathways is associated with metabolism.

2023-09-15 | GSE242293 | GEO

The Gene Expression Profile of Lung Tissue Following Sulfur Mustard Inhalation Exposure in Large Anesthetized Swine

2016-09-01 | GSE73088 | GEO

Changes in DNA methylation in lung tissue after long-term supplementation with an increased dose of cholecalciferol

Project description:Maintaining an appropriate concentration of vitamin D is essential for the proper functioning of the body regardless of age. Nowadays, there are more and more indications that vitamin D supplementation at higher than standard doses may show protective and therapeutic effects. Our study identifies differences in the body's response to long-term supplementation of cholecalciferol at an increased dose. Two groups of pigs were used in the experiment. The first group received a standard dose of cholecalciferol (grower- 2000 and finisher- 1500 IU/kg feed), and the second group received an increased dose (grower- 3000 and finisher- 2500 IU/kg feed). The animals were slaughtered when they reached breeding maturity. Then the lung tissue was collected from the animals. The material was used for RRBS sequencing. Analysis of the methylation results showed that 2349 sites were altered. However, analysis of the results of enrichment analysis using KEGG database showed no significant effect on any biological pathway.

2023-12-10 | GSE248607 | GEO

Transcriptional profiling of swine lung and hilar node after experimental infection with Actinobacillus pleuropneumoniae

2012-11-16 | GSE42317 | GEO

Transcriptional profiling of swine lung and hilar node after experimental infection with Actinobacillus pleuropneumoniae

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