Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Distinct Fibroblast Progenitor Subpopulation Expedites Regenerative Mucosal Healing by Immunomodulation

ABSTRACT: Distinct Fibroblast Progenitor Subpopulation Expedites Regenerative Mucosal Healing by Immunomodulation

PROVIDER: PRJNA900216 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR22254647_1.fastq.gz	Fastqsanger.gz
	SRR22254647_2.fastq.gz	Fastqsanger.gz
	SRR22254648_1.fastq.gz	Fastqsanger.gz
	SRR22254648_2.fastq.gz	Fastqsanger.gz
	SRR22254649_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 13

Similar Datasets

Distinct Fibroblast Progenitor Subpopulation Expedites Regenerative Mucosal Healing by Immunomodulation

Project description:Oral fibroblasts are speculated to exhibit superior healing capacity. We used scRNA-seq to investigate oral fibroblast heterogeneity in mouse and human palate tissues.

2022-12-19 | GSE217720 | GEO

A Growth Factor-Expressing Macrophage subpopulation orchestrates regenerative inflammation via GDF-15

Project description:A Growth Factor-Expressing Macrophage subpopulation orchestrates regenerative inflammation via GDF-15

| PRJNA756289 | ENA

A Growth Factor-Expressing Macrophage subpopulation orchestrates regenerative inflammation via GDF-15

Project description:A Growth Factor-Expressing Macrophage subpopulation orchestrates regenerative inflammation via GDF-15

| PRJNA691672 | ENA

A Growth Factor-Expressing Macrophage subpopulation orchestrates regenerative inflammation via GDF-15

Project description:A Growth Factor-Expressing Macrophage subpopulation orchestrates regenerative inflammation via GDF-15

| PRJNA691670 | ENA

miR-Seq on paired skin and oral mucosal wound healing

Project description:miR-Seq on paired skin and oral mucosal wound healing

| PRJNA501906 | ENA

Neotenic phenomenon in gene expression in the skin of Foxn1 deficient (nude) mice– projection for regenerative skin wound healing

Project description:Uninjured skin of adult C57BL/6J mice and mouse fetuses at 18 day of embryonic development (E18), as the models of reparative healing, and Nude and E14, as the models of regenerative healing, were characterized for their gene expression profiles by next-generation high-throughput DNA sequencing. The comparisons of gene expression profiles indicated that there were more similarities within each model of healing (Nude was more similar to E14 and B6 was more similar to E18). The analysis revealed that Nude and E14 showed in common the up-regulation of genes associated with tissue remodeling, cytoskeletal rearrangements, wound healing and immune response and the down-regulation of genes coupled to differentiation. Gene expression profiles of regenerative adult Nude mice display features of an attenuated skin development resembling that of E14 mice, thus the Nude mouse may be considered as a unique example of neoteny among mammals. The similar expression profiles of genes in the skin of both Nude and E14 mice are direct or indirect consequences of FOXN1 deficiency. FOXN1 appears to regulate the balance between cell proliferation and differentiation and its lack creates a pro-regenerative environment.

2016-12-30 | GSE71619 | GEO

Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing

Project description:Regeneration is the “holy grail” of tissue repair, but skin injury typically yields fibrotic, non-functional scars. Developing pro-regenerative therapies requires rigorous understanding of the molecular progression from injury to fibrosis or regeneration. Here, we report the divergent molecular events driving skin wound cells toward either scarring or regenerative fates. We profile scarring versus YAP inhibition-induced wound regeneration at the transcriptional (single-cell RNA-sequencing), protein (timsTOF proteomics), and tissue (extracellular matrix ultrastructural analysis) levels. Using cell surface barcoding, we integrate these data to reveal fibrotic and regenerative “molecular trajectories” of healing. We show that disrupting YAP mechanical signaling yields regenerative repair orchestrated by fibroblasts with activated Trps1 and Wnt signaling. Finally, by performing in vivo gene knockdown and overexpression in wounds, we identify Trps1 as a key regulatory gene that is necessary and partially sufficient for wound regeneration. Our findings serve as a multimodal map of wound regeneration and could have therapeutic implications for pathologic fibroses.

2022-01-24 | GSE186527 | GEO

Gene expression in human oral mucosal fibroblasts and patient-matched skin fibroblasts

Project description:Wound healing within the oral mucosa results in minimal scar formation compared to wounds within the skin. We have recently demonstrated distinct differences in the ageing profiles of cells (oral mucosal and patient-matched skin fibroblasts) isolated from these tissues. We hypothesize that the increased replicative potential of oral mucosal fibroblasts may confer upon them preferential wound healing capacities. Passage-matched early cultures of oral mucosal fibroblasts and skin fibroblasts demonstrated distinct gene expression profiles with a number of genes linked to wound healing/tissue repair. We analyzed the gene expression profiles of oral mucosal and patient-matched skin fibroblasts for multiple patients both prior to (0h) and (6h) following a wounding stimulus. Differences in the gene expression profiles of oral mucosal and patient-matched skin fibroblasts were anlazyed for multiple patients both prior to (0h) and (6h) following a wounding stimulus. Serum starvation and subsequent stimulation provides a model for wounding and RNA extracted at 0h and 6h following this stimulus was hybridized to Affymetrix microarrays for analysis. We sought to compare the expression profiles both between oral and normal fibroblasts, in both serum depleted and stimulated conditions and also compare differences between patients.

2011-01-01 | E-GEOD-21648 | biostudies-arrayexpress

Transcriptional profiling of a wound healing process in skin and oral mucosa

Project description:When compared to skin, oral mucosal wounds heal rapidly and with reduced scar formation. This study used an Affymetrix microarray platform to compare the transcriptomes of oral mucosa and skin wounds in order to identify critical differences in the healing response at these two sites. Using microarrays, we explored the differences in gene expression in skin and oral mucosal wound healing in a murine model of paired equivalent-sized wounds. Samples were examined from day 0 to day 10 and spanned all stages of the wound healing process. Unwounded matched tissue was used as a control. Tissue samples collected at each post-wounding time point, as well as control samples, were represented by 3 biological replicates.

2010-07-20 | E-GEOD-23006 | biostudies-arrayexpress

A Growth Factor-Expressing Macrophage subpopulation orchestrates regenerative inflammation via GDF-15 [scRNA-seq]

Project description:A Growth Factor-Expressing Macrophage subpopulation orchestrates regenerative inflammation via GDF-15 [scRNA-seq]

| PRJNA678349 | ENA