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Mus musculus

ABSTRACT: RNA-seq of MC903-induced atopic dermatitis (AD) mice using Ku-Gan formula

PROVIDER: PRJNA918552 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23036631_1.fastq.gz	Fastqsanger.gz
	SRR23036631_2.fastq.gz	Fastqsanger.gz
	SRR23036632_1.fastq.gz	Fastqsanger.gz
	SRR23036632_2.fastq.gz	Fastqsanger.gz
	SRR23036633_1.fastq.gz	Fastqsanger.gz

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Project description:RNA-seq of MC903-induced recurrence atopic dermatitis (AD) mice with Ku-Gan topical treatment

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Effect of RGRN-305 on MC903-induced skin inflammation in mice

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Project description:The goal of the experiment is to assess the effect of GLPG2534 and dexamethasone in the MC903 mouse model for atopic dermatitis in a therapeutic setting.

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Urotensin II/GPR14 Pathway Regulates Chronic Itch in Mice

Project description:In order to analyze the regulatory effects of UII and GPR14 on gene transcription in Mc903-induced atopic dermatitis skin, ear skin collected from MC903 chronic itch mouse model on day 13 was used for in-depth analysis and sequencing of skin gene expression. The effect of GSK1562590 on the expression of pruritus and inflammatory factors in dermatitis was detected by RNA-seq.

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Single-cell transcriptomic analysis of dermal macrophage from PDGFRa-lineage origin under atopic dermatitis

Project description:We analyzed dermal macrophage repertoire derived from PDGFRa-lineage or non-PDGFRa-lineage origin in atopic dermatitis (AD) with single-cell RNA sequencing. PDGFRa-lineage tracing mice aged between 7- and 14-week old were used to label cells of PDGFRa-lineage with tdTomato. AD was induced by topic application of MC903 bidaily or tridaily to skin of female mice for six times. Inflamed skin was excised on day 14 and single cells were prepared. Target cells were sorted as single cells for sequencing. We identified multiple subtypes in both PDGFRa-lineage or non-PDGFRa-lineage macrophage and the proportion differed by PDGFRa-lineage origin in AD skin.

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RNA-sequencing of mouse Lang+ and Lang- migratory dendritic cells (DC) under 2 pathogenic conditions of atopic dermatitis

Project description:Comparison of mouse Lang+ and Lang- migratory dendritic cells (DC) under 2 pathogenic conditions of atopic dermatitis (MC903-treated and OVA treated)

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RNA-seq of tissues from MC903- and Ethanol-treated mice

Project description:We report transcript abundance in skin, spinal_cord, and trigeminal ganglia from animals treated with MC903 to induce a mouse model of atopic dermatitis across different genotypes, time points, and treatments

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EGR1 increases the innervation density of epidermal sensory neurons via upregulation of ARTN in keratinocytes in atopic dermatitis

Project description:Atopic dermatitis (AD) is the chronic inflammatory skin disease accompanied with severe pruritus. To explore the roles of EGR1 in atopic dermatitis and the relationship between EGR1 and pruritus-scratching behavior, we used a atopic dermatitis-like mouse model driven by house dust mite (HDM) treatment in wild type and EGR1 KO mice, followed with RNA-sequencing analysis.

2024-01-15 | GSE214750 | GEO

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