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Mus musculus

ABSTRACT: RNA-seq of MC903-induced recurrence atopic dermatitis (AD) mice with Ku-Gan topical treatment

PROVIDER: PRJNA938152 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23609775_1.fastq.gz	Fastqsanger.gz
	SRR23609775_2.fastq.gz	Fastqsanger.gz
	SRR23609776_1.fastq.gz	Fastqsanger.gz
	SRR23609776_2.fastq.gz	Fastqsanger.gz
	SRR23609777_1.fastq.gz	Fastqsanger.gz

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Mus musculus

Project description:RNA-seq of MC903-induced atopic dermatitis (AD) mice using Ku-Gan formula

| PRJNA918552 | ENA

Effect of RGRN-305 on MC903-induced skin inflammation in mice

Project description:The aim was to demonstrate that RGRN-305 suppresses MC903-induced atopic dermatitis like-alterations in gene expression.

2023-12-31 | GSE246569 | GEO

Gene expression data from atopic dermatitis induced NC/Nga mouse model skin

Project description:We identified zinc-alpha-2-glycoprotein (ZAG), a 41-kDa adipokine that regulates body weight, lipid, and mobilization, as a novel biomarker for AD. ZAG levels were consistently decreased in sera, T cells, and skin in human AD patients compared with healthy controls. We used microarrays to obtain the change of signaling molecules by topical treatment of recombinant ZAG using atopic dermatitis induced mouse model.

2019-01-03 | GSE124550 | GEO

MC903 / Calcipotriol mouse model treated with GLPG2534 or dexamethasone

Project description:The goal of the experiment is to assess the effect of GLPG2534 and dexamethasone in the MC903 mouse model for atopic dermatitis in a therapeutic setting.

2023-01-15 | E-MTAB-10015 | biostudies-arrayexpress

Urotensin II/GPR14 Pathway Regulates Chronic Itch in Mice

Project description:In order to analyze the regulatory effects of UII and GPR14 on gene transcription in Mc903-induced atopic dermatitis skin, ear skin collected from MC903 chronic itch mouse model on day 13 was used for in-depth analysis and sequencing of skin gene expression. The effect of GSK1562590 on the expression of pruritus and inflammatory factors in dermatitis was detected by RNA-seq.

2023-06-16 | GSE226669 | GEO

A Phase 1b Randomized Single-Center Trial of Topical Cerdulatinib (DMVT-502) in Patients with Mild-to-Moderate Atopic Dermatitis

Project description:This phase 1b, single-center, double-blind study evaluated safety, efficacy, and effect on molecular profiles of a topical Janus kinase/spleen tyrosine kinase (JAK/Syk) inhibitor, cerdulatinib gel 0.37%, in ten adults with mild-to-moderate atopic dermatitis (AD).

2020-11-12 | GSE141570 | GEO

RNA-sequencing of mouse Lang+ and Lang- migratory dendritic cells (DC) under 2 pathogenic conditions of atopic dermatitis

Project description:Comparison of mouse Lang+ and Lang- migratory dendritic cells (DC) under 2 pathogenic conditions of atopic dermatitis (MC903-treated and OVA treated)

2023-04-20 | GSE149039 | GEO

The role of keratinocyte DDX5 in MC903-induced atopic dermatitis (AD) mice

Project description:The role of keratinocyte DDX5 in MC903-induced atopic dermatitis (AD) mice

| PRJNA860591 | ENA

Single-cell transcriptomic analysis of dermal macrophage from PDGFRa-lineage origin under atopic dermatitis

Project description:We analyzed dermal macrophage repertoire derived from PDGFRa-lineage or non-PDGFRa-lineage origin in atopic dermatitis (AD) with single-cell RNA sequencing. PDGFRa-lineage tracing mice aged between 7- and 14-week old were used to label cells of PDGFRa-lineage with tdTomato. AD was induced by topic application of MC903 bidaily or tridaily to skin of female mice for six times. Inflamed skin was excised on day 14 and single cells were prepared. Target cells were sorted as single cells for sequencing. We identified multiple subtypes in both PDGFRa-lineage or non-PDGFRa-lineage macrophage and the proportion differed by PDGFRa-lineage origin in AD skin.

2022-07-27 | GSE166855 | GEO

RNA-seq of tissues from MC903- and Ethanol-treated mice

Project description:We report transcript abundance in skin, spinal_cord, and trigeminal ganglia from animals treated with MC903 to induce a mouse model of atopic dermatitis across different genotypes, time points, and treatments

2019-11-13 | GSE132173 | GEO

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