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MRNA expression profiling of wild-type and ABCA1 knockout IMR90 cells during DNA damage-induced senescence

ABSTRACT: mRNA expression profiling of wild-type and ABCA1 knockout IMR90 cells during DNA damage-induced senescence

PROVIDER: PRJNA923006 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23053190_1.fastq.gz	Fastqsanger.gz
	SRR23053190_2.fastq.gz	Fastqsanger.gz
	SRR23053191_1.fastq.gz	Fastqsanger.gz
	SRR23053191_2.fastq.gz	Fastqsanger.gz
	SRR23053192_1.fastq.gz	Fastqsanger.gz

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mRNA expression profiling of wild-type and ABCA1 knockout IMR90 cells during DNA damage-induced senescence

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Project description:Senescence can be transmitted in a paracrine way from cells undergoing Oncogene Induced Senescence (OIS) to naM-CM-/ve normal cells. We define this phenomenon as M-bM-^@M-^\paracrine senescenceM-bM-^@M-^] We used microarrays to compare the trancriptome of cells undergoing paracrine senescence to the transcriptome of cells suffering OIS to unveil the common signatures defining both events and the similarities between them IMR90 cells were co-cultured with IMR90 ER:RAS undergoing OIS or IMR90-Vector control cells using 0.2 M-NM-<m pore transwell (anopore) to allow communication of soluble factors but physical separation of the two cell populations. The total mRNA of IMR90, IMR90 ER:RAS or IMR90 cells cultured in Transwells together with IMR90 vector or IMR90 ER:RAS cells during 7 days in the presence of 200 nM 4OHT and 0.5 % FBS was extracted and hybridized on Affymetrix microarrays to compare paracrine senescence to OIS.

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Project description:ER:RAS-G12V expressing IMR90 cells were treated with either 100nM 4-OHT for 6 days or 100uM Etoposide for 2 days, followed by further culture for 5 days, leading to RAS-induced senescence (RIS) and DNA-damage induced senescence (DDIS) respectively.

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Project description:RNA-seq of IMR90 senescence with CCF nuclear egress inhibition

| PRJNA1136149 | ENA