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MRNA expression profiling of wild-type and ABCA1 knockout IMR90 cells during DNA damage-induced senescence

ABSTRACT: We have generated ABCA1 knockout cells using CRISPR/Cas9 system and expanded single cell clones for gene expression profiling. To identify differentially expressed genes during cellular senescence in wild-type and ABCA1 knockout cells, we performed transcriptional profiling with RNA sequencing (RNA-seq) before and after senescence induction using a stress-induced senescence model (bleomycin-induced senescence).

ORGANISM(S): Homo sapiens

PROVIDER: GSE222676 | GEO | 2023/01/15

REPOSITORIES: GEO

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mRNA expression profiling of wild-type and ABCA1 knockout IMR90 cells during DNA damage-induced senescence

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