Project description:The objective of the study was to identify differentially methylated regions of DNA (DMRs) that distinguish human leukocyte subtypes, and hence serve as biomarkers for those immune cell types. This file contains Illumina Infinium HumanMethylation27 BeadChip data for human leukocyte subtypes that were purified from whole blood samples via magnetic activated cell sorting (MACS) and purity confirmed by flourescence activated cell sorting (FACS). Bisulphite converted DNA from the 73 samples were hybridised to the Illumina Infinium 27k Human Methylation Beadchip v1.2
Project description:The objective of the study was to identify differentially methylated regions of DNA (DMRs) that distinguish human leukocyte subtypes, and hence serve as biomarkers for those immune cell types. This file contains Illumina Infinium HumanMethylation27 BeadChip data for human leukocyte subtypes that were purified from whole blood samples via magnetic activated cell sorting (MACS) and purity confirmed by flourescence activated cell sorting (FACS).
Project description:Genome-wide methylation patterns observed in primary human leukocyte subsets were used to identify cell-typeM-^Vspecific regulatory hypomethylated regions. To investigate the possible effect of these regions on gene expression, a transcriptomics analysis was performed with mRNA isolated from the leukocyte subsets.
Project description:DNA methylation profiles of primary human leukocyte subsets. Complementary MeDIP-seq data for the same samples have been deposited in ArrayExpress under accession number E-ERAD-179 (https://www.ebi.ac.uk/arrayexpress/experiments/E-ERAD-179/) .