Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Extrahepatic tumors induce inflammation causing liver depletion of HNF4a and driving a systemic metabolic rewiring II

ABSTRACT: Extrahepatic tumors induce inflammation causing liver depletion of HNF4a and driving a systemic metabolic rewiring II

PROVIDER: PRJNA928486 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR23249064.fastq.gz	Fastqsanger.gz
	SRR23249065.fastq.gz	Fastqsanger.gz
	SRR23249066.fastq.gz	Fastqsanger.gz
	SRR23249067.fastq.gz	Fastqsanger.gz
	SRR23249068.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Extrahepatic tumors induce inflammation causing liver depletion of HNF4a and driving a systemic metabolic rewiring

Project description:Extrahepatic tumors induce inflammation causing liver depletion of HNF4a and driving a systemic metabolic rewiring

| PRJNA874037 | ENA

Extrahepatic tumors induce inflammation causing liver depletion of HNF4a and driving a systemic metabolic rewiring

Project description:To evaluate whether liver metabolic pathways are affected by non-hepatic cancer in-vivo, we performed RNA sequencing of hepatocytes isolated from perfused livers of WT and 4T1 breast cancer-bearing mice on days 4 and 21 following cancer cells injection.

2023-03-27 | GSE212113 | GEO

Extrahepatic tumors induce inflammation causing liver depletion of HNF4a and driving a systemic metabolic rewiring II

Project description:To identify which immune cells infiltrate the liver during exra-hepatic carcinogenesis , we performed single-cell RNA sequencing (scRNA) analysis of the non-hepatic parenchyma cells in the liver

2023-03-27 | GSE223835 | GEO

HNF4A

Project description:HNF4A

| PRJNA940175 | ENA

Molecular classification and therapeutic targets in extrahepatic cholangiocarcinoma

Project description:Genome-wide expression analysis of 182 extrahepatic cholangiocarcinoma and 38 non-tumoral bile duct samples as part of a integrated study of gene expression and targeted DNA-sequencing in patients with extrahepatic cholangiocarcinoma We used whole-genome transcriptome to conduct an unsupervised molecular classification of extrahepatic cholangiocarcinoma

2020-03-22 | GSE132305 | GEO

Mouse extrahepatic cholangiocarcinoma study

Project description:We examined the transcriptome from bile duct tissue in mice with extrahepatic cholangiocarcinoma

2024-12-31 | GSE252380 | GEO

Mouse extrahepatic cholangiocarcinoma study

Project description:Mouse extrahepatic cholangiocarcinoma study

| PRJNA1060313 | ENA

Hnf4a regulated transcriptome

Project description:Hnf4a regulated transcriptome

| PRJNA574921 | ENA

RNA-seq of mouse cell lines isolated from genetically engineered mouse models of extrahepatic cholangiocarcinoma and pancreatic cancer

Project description:Biliary tract cancer (BTC) ranks among the most lethal human malignancies, thereby representing an unmet clinical need. In this study, we find that the Pdx1-positive extrahepatic biliary epithelium is highly susceptible towards transformation by activated Pik3caH1047R, but completely refractory to oncogenic KrasG12D. Using genome-wide in vivo piggyBac transposon-based forward genetic screening and genetic loss-of-function experiments, we discover important extrahepatic cholangiocarcinoma (ECC) cancer genes and find that PI3K-signaling output strength and repression of the tumor suppressor p27Kip1 are critical context-specific determinants of tumor formation. This contrasts the pancreas, where oncogenic Kras in concert with Trp53 loss of function are key cancer drivers. Notably, inactivation of p27Kip1 permits KrasG12D-driven ECC development, and bypasses oncogene-induced senescence without triggering the Trp53 pathway. These studies provide a mechanistic link between PI3K-signaling, tissue-specific tumor suppressor barriers, and ECC pathogenesis, and present a novel genetic model of autochthonous ECC and genes driving this highly lethal tumor-subtype.

2021-07-05 | E-MTAB-10515 | biostudies-arrayexpress

Modeling extrahepatic hepatitis E virus infection in induced human primary neurons

Project description:Hepatitis E virus (HEV) infections are one of the most common causes of acute viral hepatitis, annually causing over 3 million symptomatic cases and 70,000 deaths worldwide. Historically, HEV was described as a hepatotropic virus, but has recently been associated with various extrahepatic manifestations including neurological disorders such as Guillain-Barré syndrome and neuralgic amyotrophy. However, the underlying pathogenesis of these neurological diseases remains largely unknown. The aim of this study was to investigate extrahepatic HEV manifestations in a neuronal model system using human induced primary neurons (iPNs). Renal epithelial cells from human urine were reprogrammed to induced pluripotent stem cells (iPSCs) to generate neuronal progenitor cells, which were subsequently differentiated into iPNs over 21 days. These iPNs supported HEV infection preferentially in neurite-bearing cells. Transcriptional profiling of the neuronal development process as well as viral infection dynamics in iPNs uncovered a lack of antiviral innate immune responses to HEV infection with only an intrinsic expression of distinct interferon-regulated genes (ISGs) and signaling molecules. Viral open reading frame 2 (ORF2) encoded capsid protein could be visualized by volumetric three-dimensional reconstitution within the neurites, which were reduced in length in an HEV inoculation-dependent manner. In conclusion, this neuron-derived human model system provides a powerful tool for studying extrahepatic manifestations of HEV infection. It further indicates a potential mechanism of pathogenesis driven by the interaction between host and viral factors.

2025-01-28 | GSE275473 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data