Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mll1 in T follicular helper cell differentiation

ABSTRACT: Mll1 in T follicular helper cell differentiation

PROVIDER: PRJNA939741 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Mll1 in T follicular helper cell differentiation

Project description:T follicular helper (TFH) cells are essential for developing protective antibody responses following vaccination. Greater understanding of the genetic program leading to TFH differentiation is needed. Chromatin modifications are central in the control of gene expression. However, detailed knowledge of how chromatin regulators (CRs) regulate differentiation of TFH cells is limited. We screened a large shRNA library targeting all known CRs in mouse and identified the histone methyltransferase Mll1 as a positive regulator of TFH differentiation. Loss of Mll1 expression reduced formation of TFH cells following acute viral infection or protein immunization. In addition, expression of the TFH lineage-defining transcription factor Bcl6 was reduced in the absence of Mll1. Transcriptomics analysis identified Lef1 and Tcf7 as genes dependent on Mll1 for their expression, which provides one mechanism for the regulation of TFH differentiation by Mll1. Taken together, CRs such as Mll1 substantially influence TFH differentiation.

2023-03-21 | GSE226341 | GEO

Translational regulation of T follicular helper cell differentiation

Project description:Translational regulation of T follicular helper cell differentiation

| PRJNA797081 | ENA

Transcription profiling of mouse vivo follicular helper CD4 T cells (TFH) versus non follicular helper CD4 T cells (non-TFH)

Project description:Analysis of in vivo antigen-specific (LCMV-specific, SMARTA TCR transgenic) follicular helper CD4 T cells (CXCR5high),versus non-follicular helper CD4 T cells (CXCR5low), eight days after viral infection. A paper including data analysis of these experiments has been accepted for publication (Robert J. Johnston et al. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of follicular helper CD4 T cell differentiation). Experiment Overall Design: Analysis of in vivo antigen-specific (LCMV-specific, SMARTA TCR transgenic) follicular helper CD4 T cells (CXCR5high), versus non-follicular helper CD4 T cells (CXCR5low), eight days after viral infection.

2009-08-07 | E-GEOD-16697 | biostudies-arrayexpress

Tet2-mediated epigenetic programing of T follicular helper cell differentiation

Project description:Tet2-mediated epigenetic programing of T follicular helper cell differentiation

| PRJNA759915 | ENA

Expression Data from in vivo follicular helper CD4 T cells (TFH) versus non follicular helper CD4 T cells (non-TFH)

2009-07-28 | GSE16697 | GEO

HIF-1a tunes T follicular helper cell differentiation during acute viral infection

Project description:HIF-1a tunes T follicular helper cell differentiation during acute viral infection

| PRJNA603744 | ENA

Age promotes abortive T follicular helper cell differentiation by increasing Notch signalling.

Project description:Age promotes abortive T follicular helper cell differentiation by increasing Notch signalling.

| PRJNA627949 | ENA

Tet2-mediated epigenetic programing of T follicular helper cell differentiation (ChIP-Seq)

Project description:Tet2-mediated epigenetic programing of T follicular helper cell differentiation (ChIP-Seq)

| PRJNA759917 | ENA

Tet2-mediated epigenetic programing of T follicular helper cell differentiation (Methyl-Seq)

Project description:Tet2-mediated epigenetic programing of T follicular helper cell differentiation (Methyl-Seq)

| PRJNA758390 | ENA

Tet2-mediated epigenetic programing of T follicular helper cell differentiation (RNA-Seq)

Project description:Tet2-mediated epigenetic programing of T follicular helper cell differentiation (RNA-Seq)

| PRJNA759918 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data