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Cellular response to hypoxia on human bronchial epithelial culture [scRNA-Seq]

ABSTRACT: Cellular response to hypoxia on human bronchial epithelial culture [scRNA-Seq]

PROVIDER: PRJNA945417 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23881853.fastq.gz	Fastqsanger.gz
	SRR23881854.fastq.gz	Fastqsanger.gz
	SRR23881855.fastq.gz	Fastqsanger.gz
	SRR23881856.fastq.gz	Fastqsanger.gz
	SRR23881857.fastq.gz	Fastqsanger.gz

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Cellular response to hypoxia on human bronchial epithelial culture [scRNA-Seq]

Project description:Purpose: To identify the cell types change and gene expression change under hypoxia on HBE cells. Methods: The primary human bronchial epithelial cells (HBE) were cultured on air-liquid interface (ALI) conditions. After 4 weeks, the cells were cultured under normoxic or hypoxic (1% O2) conditions for 6h or 5days. The cells were dissociated with Accutase solution and proceeded to scRNA-seq. Results: Hypoxia did not induce any hypoxia-specific cell types, however, all cell types upregulated hypoxia-related, and senescence-related genes and downregulated cell proliferation genes.

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Project description:Purpose: To identify the cell types change and gene expression change under hypoxia on HBE cells. Methods: The primary human bronchial epithelial cells (HBE) were cultured on air-liquid interface (ALI) conditions. After 4 weeks, the cells were cultured under normoxic, symmetrical hypoxic (3.5% O2), or asymmetrical hypoxic (3.5% O2 basolateral with apical cap ~ 1% O2) conditions for 5 days. The cells were dissociated with Accutase solution and proceeded to scRNA-seq. Results: Asymmetrical hypoxic cells showed more hypoxia-related responses than symmetrical hypoxic cells.

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