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Transcriptional profiling of small intestinal tissue from Apc-deficient mice, with and without DZNeP treatment

ABSTRACT: Transcriptional profiling of small intestinal tissue from Apc-deficient mice, with and without DZNeP treatment

PROVIDER: PRJNA955217 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24154903_1.fastq.gz	Fastqsanger.gz
	SRR24154903_2.fastq.gz	Fastqsanger.gz
	SRR24154904_1.fastq.gz	Fastqsanger.gz
	SRR24154904_2.fastq.gz	Fastqsanger.gz
	SRR24154905_1.fastq.gz	Fastqsanger.gz

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Transcriptional profiling of small intestinal tissue from Apc-deficient mice, with and without DZNeP treatment

Project description:The effect of EZH2 inhibitor DZNeP on the small intestine of mice deificient in Apc was examined with RNAseq.

2023-04-30 | GSE229639 | GEO

Transcription profiling of intestinal changes in APC deficient intestines following oncogenic Kras activation

Project description:Loss of APC with or without KRAS activation under the control of VilCreER

2020-10-23 | GSE152388 | GEO

Transcription profiling by array of Apc-deficient mouse small intestinal epithelium upon Msx1 depletion.

Project description:The first step in the development of human colorectal cancer is the aberrant hyperactivation of the Wnt signaling pathway, predominantly caused by inactivating mutations in the adenomatous polyposis coli (Apc) gene encoding an essential tumor suppressor. The gene encoding transcriptional factor msh homeobox 1 (Msx1) displayed robust upregulation upon Apc inactivation in intestinal epithelium isolated in mice harboring the conditional allele of the Apc gene. To identify the gene signature in the small intestine upon Msx1 depletion, small intestinal epithelium from mice harboring conditional alleles of Apc and Msx1 was isolated and the gene expression profile was compared with control mice harboring the conditional allele of Apc only.

2019-11-01 | E-MTAB-6930 | biostudies-arrayexpress

Transcriptional profiling of intestinal tissue from mice with and without Eif3h and Apc deficiency.

Project description:A profile of gene expression differences in mouse small intestine with and without short term induction of Apc and Eif3h deficiency.

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Gene expression profiling of Trop2+ cells in mouse Apc-deficient small intestinal hyperplastic epithelium

Project description:Tumor Associated Calcium Signal Transducer 2 (TACSTD2) is one of the cancer-related genes whose overexpression correlates with tumor progression and invasiveness in human colorectal cancer. TACSTD2 gene encodes for a transmembrane glycoprotein TROP2, which is implicated in altered expression of epithelial-mesenchymal transition (EMT) markers and may play a role in metastasis formation. To monitor the onset of TROP2 in hyperplastic cells and its effect on aberrant signaling potentially leading to tumor growth, we isolated epithelial cells from the mouse small intestine 7 days after disruption of the Adenomatous polyposis coli (Apc) gene. Loss of APC tumor suppressor function is the most common initial step in the development of colon cancer in humans. In the mice, the epithelial hyperproliferation occurs within a few days after Apc disruption, accompanied by the formation of ectopic crypts, followed by the formation of microadenomas over time. We performed expression profiling of Trop2+ and Trop2- hyperproliferating cells and, in addition, non-proliferating cells of the intestinal epithelium, including predominantly differentiated cells.

2022-11-29 | E-MTAB-11377 | biostudies-arrayexpress

Gene expression profiling of Trop2+ cells in mouse Apc-deficient small intestinal hyperplastic epithelium

Project description:Gene expression profiling of Trop2+ cells in mouse Apc-deficient small intestinal hyperplastic epithelium

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Gene expression profiling of Trop2+ cells in mouse Apc-deficient small intestinal early adenomas

Project description:Gene expression profiling of Trop2+ cells in mouse Apc-deficient small intestinal early adenomas

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Transcriptional profiling of mouse intestinal tissue, with or without antibiotic or sulindac treatment

Project description:Loss of APC or activation of Braf V600E mutation in combination with Alk5 loss in the intestinal epithelium under the control of VilCreER, with or without antibiotic/sulindac treatment

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Transcriptome analysis of Brg1 deficient small intestinal epithelium in the context of normal and aberrant Wnt signalling

Project description:Brg1 has been reported to act as a trans-activator for the Wnt pathway by interacting with beta-catenin. Given this interaction and the crucial role Wnt signalling plays in the intestinal homeostasis, we aimed to investigate the effect of Brg1 loss on gene expression in normal and Wnt activated small intestinal epithelium. We used VillinCreERT2 Cre recombinase and loxP targeted allels of Brg1 and Apc to generate 4 cohorts of conditional knock-out mice: Cre-negative controls (n=4), Brg1 deficient (n=4), Apc deficient (n=3) and double Brg1-Apc deficient (n=4). All mice were induced by 4x80mg/kg daily injections of Tamoxifen. Epithelium enriched (gut scrapes) samples of small intestine (jejunum) were collected at day 4 post induction. Loss of Brg1 expression in the small intestinal epithelium at this time point was confirmed by immunohistochemistry.

2013-08-07 | E-GEOD-46129 | biostudies-arrayexpress

microRNAs differentially regulated in organoids derived from tumors of Apc-deficient mice

Project description:microRNA expression profiles were investigated in organoids derived from tumors of Apc-deficient mice and normal intestinal epitehlia of wild-type mice.

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