Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptional profiling of multiple tissues from mice with and without Apc deficiency

ABSTRACT: Transcriptional profiling of multiple tissues from mice with and without Apc deficiency

PROVIDER: PRJNA957613 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	SRR24223900_1.fastq.gz	Fastqsanger.gz
	SRR24223900_2.fastq.gz	Fastqsanger.gz
	SRR24223901_1.fastq.gz	Fastqsanger.gz
	SRR24223901_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 189

Similar Datasets

Transcriptional profiling of multiple tissues from mice with and without Apc deficiency

Project description:The effect of whole body Apc deficiency on multiple mouse tissues was examined with RNAseq.

2023-04-28 | GSE230110 | GEO

Transcriptional profiling of intestinal tissue from mice with and without Eif3h and Apc deficiency.

Project description:A profile of gene expression differences in mouse small intestine with and without short term induction of Apc and Eif3h deficiency.

2024-02-26 | GSE256223 | GEO

Transcriptional profiling of regional intestinal tissue from mice with and without Apc deficiency

Project description:Transcriptional profiling of regional intestinal tissue from mice with and without Apc deficiency

| PRJNA957731 | ENA

Transcriptional profiling of intestinal tissue from mice with and without Eif3h and Apc deficiency.

Project description:Transcriptional profiling of intestinal tissue from mice with and without Eif3h and Apc deficiency.

| PRJNA1078723 | ENA

Impact of beta-arrestin-2 deficiency on intestinal tumorigenesis in Apc-mutated mice

Project description:This SuperSeries is composed of the following subset Series: GSE24575: Beta-arrestin-2 deficiency effect on intestinal tumorigenesis in Apc-mutated mice GSE24576: Gene expression analysis of tumors from ApcD14/+ mice Refer to individual Series

2012-01-20 | E-GEOD-24577 | biostudies-arrayexpress

Transcriptional profiling of regional intestinal tissue from mice with and without Apc deficiency

Project description:A profile of gene expression differences along the length of the mouse intestine, in the presence and absence of functional Apc.

2023-04-28 | GSE230144 | GEO

NIA/NIH AGEMAP Multiple Tissues

Project description:NIA/NIH AGEMAP Multiple Tissues

| PRJNA103897 | ENA

B-catenin deficiency, but not c-Myc deletion, suppresses the immediate phenotypes of Apc loss in the liver

Project description:Dysregulated Wnt signalling is seen in approximately 30% of hepatocellular cancers, thus finding pathways downstream of activation of Wnt signalling is key. Using cre lox technology we have deleted the the adenomatous polyposis coli tumour suppressor protein (Apc) within the adult mouse liver and observed a rapid increase in nuclear beta-catenin and C-Myc. This is associated with an induction of proliferation leading to hepatomegally within 4 days of gene deletion. To investigate the downstream pathways responsible for these phenotypes we analysed the impact of inactivating Apc in the context of deficiency of the potentially key effectors beta-catenin and c-Myc. beta-catenin loss rescues both the proliferation and hepatomegally phenotypes following Apc loss. However c-Myc deletion, which rescues the phenotypes of Apc loss in the intestine, had no effect on the phenotypes of Apc loss. The consequences of deregulation the Wnt pathway within the liver are therefore strikingly different to those observed within the intestine, with the vast majority of Wnt targets beta-catenin dependent but c-Myc independent in the liver. Samples were collected from Genetcially modified mice of the genotypes indicated in the characteristics field. Gene recombination was induced using IP administration of beta-napthoflavone. Cohorts of samples were used to compare the affects of APC loss, cMYC loss and combined APC and cMYC loss in the liver (and compared to matched control samples in which the genes were not recombined).

2015-01-31 | E-GEOD-65476 | biostudies-arrayexpress

B-catenin deficiency, but not c-Myc deletion, suppresses the immediate phenotypes of Apc loss in the liver

2015-01-31 | GSE65476 | GEO

Transcriptional profiling of SI adenomas in Apc floxed mice

Project description:Small intestinal adenomas in mice with Apc deficiency following tamoxifen-induced genetic recombination.

2021-02-19 | GSE167008 | GEO